2型糖尿病患者合并骨量减少的危险因素分析  

Analysis on Risk Factors of Patients with Type 2 Diabetes Mellitus and Osteopenia

作　　者：陈璐[1] 钱凤娟[1] 张敏[1] CHEN Lu;QIAN Fengjuan;ZHANG Min(The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou),Changzhou 213000,China)

机构地区：[1]苏州大学附属第三医院(江苏省常州市第一人民医院),江苏常州213000

出　　处：《中国医学创新》2021年第35期31-34,共4页Medical Innovation of China

摘　　要：目的:探究与分析2型糖尿病患者合并骨量减少的危险因素。方法:选取2016年2月-2018年8月本院的300例2型糖尿病患者为研究对象,将其根据骨量的不同分为骨量正常组(n=103)和骨量减少组(n=197)。比较两组性别、年龄、病程、BMI、腹围、腰臀比、FBG、HbA1c、脂代谢指标(TG、TC、LDL-C及HDL-C)、吸烟史、饮酒史、SBP、DBP、高尿蛋白/肌酐、糖尿病视网膜病变、血清ALP、UA及钙,采用多因素logistic回归分析处理2型糖尿病患者合并骨量减少的危险因素。结果:两组性别、年龄、病程、FBG、HbA1c、脂代谢指标、饮酒史、SBP、DBP、糖尿病视网膜病变情况及血清钙比较,差异均无统计学意义(P>0.05);两组BMI、腹围、腰臀比、吸烟史、高尿蛋白/肌酐及血清ALP、UA比较,差异均有统计学意义(P<0.05)。多因素logistic回归分析显示,BMI、腹围、吸烟史、尿蛋白/肌酐及ALP、UA均是2型糖尿病患者合并骨量减少的危险因素(P<0.05)。结论:2型糖尿病患者合并骨量减少的危险因素涉及BMI、腹围、吸烟史、尿蛋白/肌酐、ALP及UA,应重视对2型糖尿病患者上述因素的监测、评估与调控。Objective:To investigate and analyze the risk factors of patients with type 2 diabetes mellitus and osteopenia.Method:A total of 300 patients with type 2 diabetes mellitus from February 2016 to August 2018 were chosen as the study objects,and they were divided into normal bone mass group (n=103) and osteopenia group (n=197) according to the differences of bone mass.Then the gender,ages,disease course,BMI,abdominal circumference,waist-hip ratio,FBG,HbA1c,lipid metabolism indexes (TG,TC,LDL-C and HDL-C),smoking history,drinking history,SBP,DBP,high urinary protein/creatinine and diabetic retinopathy and serum ALP,UA and calcium of two groups were compared,and the risk factors of osteopenia in patients with type 2 diabetes mellitus were analyzed with multivariate logistic regression analysis.Result:The gender,ages,disease course,FBG,HbA1c,lipid metabolism indexes,drinking history,SBP,DBP,diabetic retinopathy and serum calcium of two groups were compared,there were no statistically significant differences (P>0.05);the BMI,abdominal circumference,waist-hip ratio,smoking history,high urinary protein/creatinine and serum ALP,UA of two groups were compared,there were statistically significant differences (P<0.05).The multivariate logistic regression analysis showed BMI,abdominal circumference,smoking history,urinary protein/creatinine,ALP and UA were the risk factors of patients with type 2 diabetes mellitus and osteopenia (P<0.05).Conclusion:The risk factors of patients with type 2 diabetes mellitus and osteopenia include BMI,abdominal circumference,smoking history,urinary protein/creatinine,ALP and UA,so those factors of patients with type 2 diabetes mellitus should be paid to more monitoring,evaluation and regulation.

关 键 词：2型糖尿病 骨量减少 危险因素 

分 类 号：R587.2[医药卫生—内分泌]