β-二酮二氟化硼衍生物的合成及生物成像研究  

Synthesis and Bioimaging of Difluoroboronβ-diketone Derivatives

作　　者：沈舒婷 于坤 王亚轩 吴运军 王慧 SHEN Shuting;YU Kun;WANG Yaxuan;WU Yunjun;WANG Hui(School of Pharmacy,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]皖南医学院药学院,安徽芜湖241002

出　　处：《海南师范大学学报（自然科学版）》2021年第4期365-370,共6页Journal of Hainan Normal University（Natural Science）

基　　金：安徽省自然科学基金青年项目(1908085QB50);国家级大学生创新创业训练计划项目(202110368056);皖南医学院大学生科研资助项目(WK2021XS44)。

摘　　要：以β-二酮二氟化硼和咪唑为原料,通过简单高效的路线合成了一种化合物L,通过现代分析测试技术(包括核磁共振波谱、质谱和红外光谱)对其结构进行了表征。利用紫外可见吸收光谱和荧光光谱研究了化合物L的光物理性质以及外部因素对其荧光光谱的影响。由于化合物L具有较低的细胞毒性和较好的脂溶性,可靶向在细胞内的膜结构上,因此成功地将其用于组织成像实验中。Anew difluoroboron compound L was synthesized usingβ-diketone difluoride boron and imidazole as raw materials.The chemical structure was characterized by modern analytical techniques including NMR,MS and IR.The photophysical properties of compound L and the effect of external environment factors on its fluorescence spectra were investigated by UV-vis absorption and fluorescence spectra.Due to its low cytotoxicity and good lipid solubility,compound L can be targeted to the membrane structure in cells and successfully applied in tissue imaging experiments.

关 键 词：β二酮二氟化硼 咪唑 膜结构 细胞成像 

分 类 号：O625.6[理学—有机化学]