Molecular mechanisms and roles of inflammatory responses on low-frequency residual hearing after cochlear implantation  

作　　者：Juanjuan Gao Haijin Yi 

机构地区：[1]Department of Otolaryngology,Head&Neck Surgery,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing,102218,China

出　　处：《Journal of Otology》2022年第1期54-58,共5页中华耳科学杂志（英文版）

摘　　要：Preservation of low-frequency residual hearing is very important for combined electro-acoustic stimulation after cochlear implantation.However,in clinical practice,loss of low-frequency residual hearing often occurs after cochlear implantation and its mechanisms remain unclear.Factors affecting lowfrequency residual hearing after cochlear implantation are one of the hot spots in current research.Inflammation induced by injury associated with cochlear implantation is deemed to be significant,as it may give rise to low-frequency residual hearing loss by interfering with the blood labyrinth barrier and neural synapses.Pathological changes along the pathway for low-frequency auditory signals transmission may include latent factors such as damage to neuroepithelial structures,synapses,stria vascularis and other ultrastructures.In this review,current research on mechanisms of low-frequency residual hearing loss after cochlear implantation and possible roles of inflammatory responses are summarized.

关 键 词：Low-frequency residual hearing loss Cochlear implantation Electro-acoustic stimulation(EAS) Inflammatory response Blood labyrinth barrier(BLB) 

分 类 号：R764.5[医药卫生—耳鼻咽喉科]