褪黑素在牛体外胚胎生产中的应用研究进展  

Advance in Application of Melatonin in Bovine Embryo Production in vitro

作　　者：阎来庆 刘雪凝 刘巧香 刘国世[1] YAN Laiqing;LIU Xuening;LIU Qiaoxiang;LIU Guoshi(College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;Beijing Capital Agribusiness&Foods Group,Beijing 100028,China)

机构地区：[1]中国农业大学动物科学技术学院,北京100193 [2]北京首农食品集团有限公司,北京100028

出　　处：《中国畜牧杂志》2022年第2期1-5,共5页Chinese Journal of Animal Science

基　　金：奶牛产业体系北京市创新团队(BAIC06-21)。

摘　　要：近年来牛体外胚胎生产取得很大进展,可以稳定地在体外获得囊胚,但体外生产效率偏低,不能满足产业需要。在牛体外胚胎生产过程中很容易产生活性氧和活性氮,导致配子和胚胎受到氧化应激或硝化应激。褪黑素作为一种强有力的抗氧化剂和抗凋亡剂,可以直接清除有毒的氧衍生物,减少活性氧的形成,在牛体外胚胎生产过程中发挥积极作用。本文主要对褪黑素在牛卵母细胞体外成熟、体外受精、早期胚胎发育、配子和胚胎冷冻保存等方面的研究进行综述,为后续体外胚胎生产技术的优化研究和推广应用提供参考。In recent years,the production of bovine embryos in vitro has made great progress,and blastocysts can be obtained stably in vitro,but the efficiency of in vitro production is low and could not meet the needs of the industry.Reactive oxygen species and reactive nitrogen are easily produced during bovine embryo production in vitro,resulting in oxidative stress or nitrification stress on gametes and embryos.As a powerful antioxidant and anti-apoptotic agent,melatonin can directly remove toxic oxygen derivatives,reduce the formation of reactive oxygen species,and play an active role in bovine embryo production in vitro.This paper mainly reviews the studies of melatonin in in vitro maturation,in vitro fertilization,early embryo development,gamete and embryo cryopreservation of bovine oocytes,in order to provide reference for the optimization and application of in vitro embryo production.

关 键 词：褪黑素 牛胚胎 体外生产 冷冻保存 

分 类 号：S828.3[农业科学—畜牧学]