沙丁胺醇联合布地奈德雾化吸入对小儿支气管哮喘气道重塑和炎性反应的影响  

Effect of Salbutamol Combined with Budesonide Atomization Inhalation on Airway Remodeling and Inflammatory Response in Children With Bronchial Asthma

作　　者：赵惯军[1] 贾耀丽 张惠霞[2] ZHAO Guan-jun;JIA Yao-li;ZHANG Hui-xia(Department of NICU,Pingdingshan First People's Hospital,Pingdingshan 467000,Henan Province,China;Department of Pediatrics,Pingdingshan First People's Hospital,Pingdingshan 467000,Henan Province,China)

机构地区：[1]平顶山市第一人民医院NICU,河南平顶山467000 [2]平顶山市第一人民医院普儿一科,河南平顶山467000

出　　处：《罕少疾病杂志》2022年第3期41-43,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨沙丁胺醇联合布地奈德雾化吸入对小儿支气管哮喘气道重塑和炎性反应的影响。方法回顾性选择2017年2月至2020年10月于新生儿重症监护病房接受的139例支气管哮喘患儿,根据治疗方法不同将入组患儿分为观察组75例和对照组64例,其中对照组给予硫酸沙丁胺醇,观察组在以上基础联合布地奈德雾化吸入。观察两组临床疗效,并比较症状改善时间、气道重塑指标、血清炎症因子水平的变化及不良反应发生情况。结果观察组总有效率显著高于对照组(P<0.05);观察组肺部湿啰音缓解时间、喘息平缓时间、咳嗽消失时间、平均住院时间均短于对照组(P<0.05);观察组气道重塑指标及血清炎症因子水平的改善程度优于对照组(P<0.05);两组不良反应发生率比较无统计学意义(P>0.05)。结论硫酸沙丁胺醇注射液联合布地奈德雾化吸入治疗用于小儿支气管哮喘中,疗效显著,不仅能缩短症状改善时间,还能改善气道重塑指标及血清炎症因子水平,安全性较好,值得推广运用。Objective To investigate the effect of salbutamol combined with budesonide atomization inhalation on airway remodeling and inflammatory response in children with bronchial asthma.Methods This study retrospectively reviewed 139 children with bronchial asthmaadmitted to the neonatal intensive care unit from February 2017 to October 2020.According to the treatment method,the enrolled children were divided into observation group(75 cases)and control group(64 cases).The control group was treated with salbutamol sulfate,and on this basis,the observation group was treated with budesonide atomization inhalation.Clinical effects of the two groups were observed.The improvement time of clinical symptoms,changes inairway remodeling indicators and serum inflammatory factors,andadverse reactions were compared between the two groups.Results The total response rate in the observation group wassignificantly higher than that in the control group(P<0.05).The remission time of lung wet rales,wheezing relief time,cough disappearing time,and average hospital stay of the observation group were shorter than those of the control group(P<0.05).The improvement of airway remodeling indicators and serum inflammatory factors in the observation group was better than that in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Salbutamol sulfate injection combined with budesonide atomization inhalation is markedly effective in the treatment of pediatric bronchial asthma.It can not onlyshorten the improvement time of symptoms but also improve airway remodelingindicators and serum inflammatory factors,with good safety.

关 键 词：沙丁胺醇 布地奈德 雾化吸入 小儿支气管哮喘 气道重塑 肺功能 炎性反应 

分 类 号：R725[医药卫生—儿科] R562.2[医药卫生—临床医学]