知柏地黄丸联合醋酸曲普瑞林在女童中枢性性早熟中的效果观察  

Observation on the Effect of Zhibai Dihuang Pill Combined with Triptorelin Acetate on Gentral Precocious Pubety in Girls

作　　者：黄占克[1] HUANG Zhanke(Department of Pediatrics, Third People’s Hospital, Luohe Henan 462000, China)

机构地区：[1]漯河市第三人民医院儿科,河南漯河462000

出　　处：《河南医学高等专科学校学报》2022年第1期10-14,共5页Journal of Henan Medical College

摘　　要：目的探讨知柏地黄丸联合醋酸曲普瑞林在女童中枢性性早熟中的应用效果及对性激素水平与不良反应发生率的影响。方法选取86例中枢性性早熟女童,依据随机数字表法分为对照组与观察组,各43例。对照组应用知柏地黄丸治疗,观察组在对照组基础上应用醋酸曲普瑞林治疗。比较2组治疗效果、不良反应、血清激素水平、生长发育、卵泡直径、子宫容积及卵巢容积。结果观察组总有效率为97.7%,高于对照组的79.1%,差异有统计学意义(P<0.05)。观察组不良反应发生率为18.6%,对照组为20.9%,差异无统计学意义(P>0.05)。对照组、观察组血清雌激素(E2)分别为(14.4±4.2)ng·L^(-1)、(9.9±3.1)ng·L^(-1),血清促卵泡生成素(FSH)分别为(3.5±1.3)ng·L^(-1)、(1.5±1.1)ng·L^(-1),血清促黄体酮生成素(LH)分别为(1.1±0.4)mIU·mL^(-1)、(0.6±0.1)mIU·mL^(-1),观察组血清E2、FSH、LH水平低于对照组,差异有统计学意义(P<0.05)。治疗前2组生长发育指标差异无统计学意义(P>0.05);治疗后对照组、观察组生长速度分别为(2.4±0.3)cm·a^(-1)、(3.3±0.5)cm·a^(-1),身高分别为(126.8±2.6)cm、(132.7±2.7)cm,骨龄增长/年龄增长分别为(0.8±0.3)、(0.5±0.1),骨龄分别为(11.4±0.7)岁、(10.8±0.8)岁,与对照组比较,观察组生长速度、身高更高,骨龄增长/年龄增长、骨龄更小,差异有统计学意义(P<0.05)。治疗前2组卵泡直径、子宫容积、卵巢容积差异无统计学意义(P>0.05);治疗后对照组、观察组卵泡直径分别为(5.9±1.3)mm、(4.2±1.0)mm,子宫容积分别为(3.7±0.4)mL、(3.1±0.3)mL,卵巢容积分别为(1.7±0.3)mL、(1.4±0.2)mL,观察组卵泡直径、子宫容积、卵巢容积小于对照组,差异有统计学意义(P<0.05)。结论知柏地黄丸与醋酸曲普瑞林联合治疗女童中枢性性早熟,临床效果较好,治疗更加安全。Objective To explore the effect of Zhibai Dihuang Pill combined with triptorelin acetate in the treatment of central precocious puberty in girls and its influence on the level of sex hormones and the incidence of adverse reactions.Methods 86 girls with central precocious puberty girls were selected and divided into a control group and an observation group according to the random number table method,with 43 cases in each group.Cases in the control group were treated with Zhibai Dihuang Pill,and other in the observation group were treated with triptorelin acetate on the basis of the control group.The treatment effects,adverse reactions,serum hormone levels,growth and development,follicle diameter,uterine volume,and ovarian volume were compared between the two groups.Results The total effective rate of the observation group(97.7%)was highter than that of the control group(79.1%)and the difference was statistically significant(P<0.05).The incidence of adverse reactions was 18.6%in the observation group and 20.9%in the control group,and the difference was not statistically significant(P>0.05).The serum E2 levels of the control group and the observation group were(14.4±4.2)ng·L^(-1)and(9.9±3.1)ng·L^(-1),and the serum FSH levels were(3.5±1.3)ng·L^(-1)and(1.5±1.1)ng·L^(-1)and serum LH levels were(1.1±0.4)mIU·mL^(-1)and(0.6±0.1)mIU·mL^(-1),respectively.Serum E2,FSH and LH levels in the observation group were lower than those in the control group(P<0.05).There was no significant difference in growth and development indexes between the two groups before treatment(P>0.05);After treatment,the growth rates of the control group and observation group were(2.4±0.3)cm·a^(-1) and(3.3±0.5)cm·a^(-1),and the heights were(126.8±2.6)cm and(132.7±2.7)cm,the increase of bone age increase/age increase was(0.8±0.3)and(0.5±0.1)and the bone age is(11.4±0.7)years old and(10.8±0.8)years old,respectively.Compared with the control group,the observation group had higher growth rate,higher height,increased bone age/aged,and yo

关 键 词：中枢性性早熟 知柏地黄丸 醋酸曲普瑞林 性激素水平 

分 类 号：R725.8[医药卫生—儿科]