血清白蛋白及前白蛋白水平与非囊性纤维化支气管扩张症患者疾病严重程度关系  

Relationship between serum albumin and prealbumin levels and disease severity in patients with non-cystic fibrosis bronchiectasis

作　　者：范洪涛 黄小平[1] 颜美好 黄文铖 洪原城 黄鑫成 黄种杰 洪丽月 FAN Hongtao;HUANG Xiaoping;YAN Meihao;HUANG Wencheng;HONG Yuancheng;HUANG Xincheng;HUANG Zhongjie;HONG Liyue(Department of respiratory,the 910 Hospital of the Joint Logistics Support Force of PLA,Quanzhou,Fujian 362000,China)

机构地区：[1]中国人民解放军联勤保障部队第九一〇医院呼吸科,福建泉州362000

出　　处：《重庆医学》2022年第3期423-427,共5页Chongqing medicine

基　　金：福建省医学创新课题(2018-CX-36)。

摘　　要：目的探讨血清白蛋白、前白蛋白水平与非囊性纤维化支气管扩张症(NCFB)患者病情严重程度的相关性。方法回顾性分析2017年1月至2020年12月该院收治的165例NCFB患者的临床资料。计算支气管扩张严重程度指数(BSI)评分和FACED评分,Leicester咳嗽问卷(LCQ)、慢性阻塞性肺疾病评估试验(CAT)。采用Pearson相关性分析及多元线性回归分析确定患者白蛋白、前白蛋白、体重指数(BMI)与疾病严重程度、肺功能和影像学的相关性。结果Pearson相关性分析显示,BSI评分比FACED评分与患者LCQ得分、CAT得分相关系数更大。根据BSI评分将患者分为轻度、中度、重度3组。重度NCFB患者的前白蛋白、白蛋白、BMI水平均为最低(P<0.05)。线性相关分析显示,前白蛋白、白蛋白水平与用力肺活量(FVC)/预测值、1秒用力呼气容积(FEV1)/预测值、用力呼出25%肺活量的呼气流量(FEF25)/预测值、用力呼出50%肺活量的呼气流量(FEF50)/预测值和肺一氧化碳弥散量(DLCO)/预测值呈正相关(P<0.05)。多元线性回归分析提示,患者血清白蛋白水平与BSI评分和改良Reiff评分独立相关(P<0.05)。结论血清白蛋白水平与NCFB患者的BSI评分、LCQ得分、CAT得分具有较强相关性,且前白蛋白水平与患者肺功能下降相关性更高。Objective To investigate the correlation between serum albumin and prealbumin levels and the severity of non-cystic fibrosis bronchiectasis.Methods The clinical data of 165 patients with non-cystic fibrosis bronchiectasis in this hospital were analyzed retrospectively.The bronchiectasis severity index(BSI)score and FACED score,Leicester Cough Questionnaire(LCQ),and chronic obstructive pulmonary disease assessment test(CAT)were calculated.The pearson correlation analysis and multiple linear regression analysis were used to determine the correlation between albumin,prealbumin,body mass index(BMI)and disease severity,lung function,and imaging.Results Pearson correlation analysis showed that the BSI score was more correlated with LCQ score and CAT score than the FACED score.The patients were divided into the mild,moderate,and severe groups according to the BSI score.The levels of prealbumin,albumin and BMI were the lowest in patients with severe non-cystic fibrosis bronchiectasis(P<0.05).The linear correlation showed that the levels of prealbumin and albumin were positively correlated with FVC/predicted value,FEV1/predicted value,FEF25/predicted value,FEF50/predicted value,and DLCO/predicted value(P<0.05).Multiple linear regression analysis showed that serum albumin level was independently correlated with BSI score and modified Reiff score(P<0.05).Conclusion Serum albumin level isstronglycorrelated with the BSI score,LCQ score,and CAT score in patients with non-cystic fibrosis bronchiectasis,and the prealbumin level was more associated with decreased pulmonary function decline.

关 键 词：非囊性纤维化支气管扩张症 前白蛋白 白蛋白 体重指数 

分 类 号：R562.22[医药卫生—呼吸系统]