全身动态辐射监测系统在^(131)I治疗分化型甲状腺癌患者出院时间个性化评估中的应用  

Application of whole-body dynamic radiation monitoring system in personalized evaluation of discharge time for thyroid cancer patients treated with^(131)I

作　　者：冉紫蕴 李群 齐小梅 苏娥 陈杰 厉红民 杨航 黄定德 RAN Ziyun;LI Qun;QI Xiaomei;SU E;CHEN Jie;LI Hongmin;YANG Hang;HUANG Dingde(Department of Nuclear Medicine,the First Affiliated Hospital of Army Medical University,Chongqing 400038,China)

机构地区：[1]陆军军医大学第一附属医院核医学科,重庆400038

出　　处：《重庆医学》2022年第3期428-431,共4页Chongqing medicine

基　　金：重庆市技术创新与应用发展专项面上项目(cstc2019jscx-msxmX0199)。

摘　　要：目的探讨全身动态辐射监测系统在^(131)I治疗分化型甲状腺(DTC)癌患者出院时间个性化评估中的应用价值。方法采用回顾性研究方法,选取2020年11月至2021年4月在该院接受^(131)I治疗的200例DTC患者,根据^(131)I剂量分为低剂量组124例和高剂量组76例,使用全身动态辐射监测系统与服^(131)I后24、48、72 h测定体内放射性残留活度(Rrav),并监测患者出院当天接触物品与环境表明射线剂量水平。结果低剂量组与高剂量组的^(131)I治疗剂量分别为(1653.71±346.20)MBq、(5426.49±851.31)MBq,两组服碘后随时间推移Rrav迅速下降,其中低剂量组24、48 h的Rrav均明显低于高剂量组(P<0.05);低剂量组24、48 h出院率分别为95.97%、100.00%,而高剂量组24、48、72 h依次为10.53%、80.26%、100.00%,其中低剂量组24、48 h出院达标率均明显高于高剂量组,差异均有统计学意义(P<0.001);两组患者出院当天病服、床单、病房地面、洗手间地面射线剂量水平均低于辐射限制水平,差异无统计学意义(P>0.05)。结论全身动态辐射监测系统可直接地动态监测^(131)I治疗DTC患者Rrav。Objective To investigate the application value of whole-body dynamic radiation monitoring system in the assessment of discharge time of thyroid cancer patients treated with^(131)I.Methods A retrospective study was used,and a total of 200 differentiated thyroid carcinoma(DTC)patients who were treated with^(131)I in the hospital from November 2020 to April 2021 were selected.According to the^(131)I dose,the patients were divided into the low-dose group(124 cases)and the high-dose group(76 cases).The residual radioactive activity in the body(Rrav)was measured by the whole-body dynamic radiation monitoring system at 24 h,48 h,72 h after taking^(131)I,and the patient′s exposure to the objects and the environment on the day of discharge were monitored to indicate the radiation dose level.Results The^(131)I treatment doses of the low-dose group and the high-dose group were(1,653.71±46.20)MBq and(5,426.49±51.31)MBq,respectively.After taking iodine,the Rrav decreased rapidly with time,and the Rrav of the low-dose group at 24 h and 48 h was significantly lower than those of the high-dose group(P<0.05).The discharge rates of 24 h and 48 h were 95.97%and 100.00%respectively in the low-dose group,while those of 24 h,48 h and 72 h were 10.53%,80.26%and 100.00%in the high-dose group.The discharge rates of 24 h and 48 h in the low-dose group were significantly higher than those in the high-dose group,and the differences were statistically significant(P<0.001).There was no significant difference between the radiation dose levels of the ward floor and washroom floor of the two groups on the day of discharge(P>0.05),all of which were lower than the radiation limit level.Conclusion The whole-body dynamic radiation monitoring system can directly and dynamically monitor^(131)I treatment of DTC patients with Rrav.

关 键 词：全身动态辐射监测系统 ^(131)I 甲状腺癌 辐射防护 出院时间 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]