LncRNAs在过敏性疾病中的研究进展  

Research progress of lncRNAs in allergic diseases

作　　者：王晓钰 肖洁 薛玲[1] WANG Xiao-yu;XIAO Jie;XUE Ling(School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China)

机构地区：[1]山东中医药大学药学院,山东济南250355

出　　处：《中国药理学通报》2022年第2期168-172,共5页Chinese Pharmacological Bulletin

基　　金：国家科技重大专项(No 2017ZX09301064);山东省医药卫生科技发展计划项目(No 202002070917);山东省中医药科技项目(No 2020Q003);山东中医药大学情志病症研究科研创新团队、山东中医药大学情志病症肝藏象药理青年科研创新团队资助(No 22202112)。

摘　　要：过敏性疾病发病率逐年增长,严重威胁人类健康,明确过敏性疾病的发病机制,发现安全有效的诊疗药物和方案是目前要解决的关键问题。长链非编码RNA(long non-coding RNAs,lncRNAs)大小超过200个碱基,异常表达的lncRNA能够通过调节基因表达参与许多关键的细胞过程,如生长、分化和凋亡。lncRNAs在癌症等多种疾病的病理过程,尤其在免疫细胞以及免疫微环境调控方面越来越受到关注。近年研究发现,lncRNAs在过敏性疾病的发病机制中扮演重要角色,特异性的lncRNA有望成为过敏性疾病诊断和治疗的新靶点。The incidence of allergic diseases has been increasing year by year,which threatens human health to a greater extent.The key issues to be solved at present are to clarify the pathogenesis of allergic diseases and to find safe and effective drugs and programs for its diagnosis and treatment.Long non-coding RNAs(lncRNAs)are larger than 200 nucleotides.Abnormally expressed lncRNAs are involved in many key cellular processes,such as growth,differentiation,and apoptosis.LncRNAs have attracted more and more research attention in the pathological process of cancer and other diseases,especially in the regulation of immune cells and immune microenvironment.Recent studies have found that lncRNAs play an important role in the pathogenesis of allergic diseases,and specific lncRNAs are expected to become a new target for the diagnosis and treatment of allergic diseases.

关 键 词：lncRNAs 过敏性疾病 过敏性哮喘 特应性皮炎 过敏性鼻炎 靶点 

分 类 号：R342.2[医药卫生—基础医学] R394.2