补中益气汤加减联合雷贝拉唑钠肠溶胶囊、枸橼酸莫沙必利分散片治疗反流性食管炎的临床疗效及对临床症状、生活质量的影响  

Clinical Efficacy of Modified Buzhong Yiqi Decoction Combined with Rabeprazole Sodium Enteric-Coated Capsules and Mosapride Citrate Dispersible Tablets in the Treatment of Reflux Esophagitis and Its Effects on Clinical Symptoms and Life Quality

作　　者：陈明[1] 季红莉[1] 路琴[1] 黄慧[1] 张汾燕[1] 谢瑞华 付万发[1] CHEN Ming;JI Hongli;LU Qin;HUANG Hui;ZHANG Fenyan;XIE Ruihua;FU Wanfa(Dept.of Gastroenterology,Beijing Geriatric Hospital,Beijing 100095,China)

机构地区：[1]北京老年医院消化科,北京100095

出　　处：《中国医院用药评价与分析》2022年第1期25-28,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：北京市医院管理局消化内科学科协同发展中心立项项目(No.XXT29)。

摘　　要：目的:探讨补中益气汤加减联合雷贝拉唑钠肠溶胶囊、枸橼酸莫沙必利分散片治疗反流性食管炎的临床疗效及对患者临床症状、生活质量的影响。方法:将2019年9月至2020年9月该院收治的92例反流性食管炎患者根据随机数字表法分为两组。对照组患者(46例)服用雷贝拉唑钠肠溶胶囊、枸橼酸莫沙必利分散片治疗,观察组患者(46例)在对照组的基础上予以补中益气汤加减治疗,连续治疗8周。观察两组患者治疗前、治疗8周后的胃肠激素水平、食管黏膜组织氧化应激指标、中医证候评分和生活质量评分变化情况,分析临床疗效和不良反应发生情况。结果:观察组患者的总有效率为95.65%(44/46),明显高于对照组的80.43%(37/46),差异有统计学意义(P<0.05)。与治疗前比较,两组患者治疗后血清胃动素、胃泌素和食管黏膜组织总超氧化物歧化酶水平均升高,健康调查简表总评分、躯体健康评分和精神健康评分均升高,食管黏膜组织一氧化氮、丙二醛水平均降低,中医证候各项评分(胸胁胀满、吞酸烧心、呃逆嗳气和情志抑郁)降低;且观察组患者上述指标和评分明显优于对照组,差异均有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为10.87%(5/46)、8.70%(4/46),差异无统计学意义(P>0.05)。结论:补中益气汤加减联合雷贝拉唑钠肠溶胶囊、枸橼酸莫沙必利分散片治疗反流性食管炎的临床疗效较好,可有效缓解患者各项临床症状,改善胃肠激素水平和食管黏膜氧化应激反应,提高患者生活质量,且不良反应少。OBJECTIVE:To probe into the clinical efficacy of modified Buzhong Yiqi decoction combined with Rabeprazole sodium enteric-coated capsules and Mosapride citrate dispersible tablets in the treatment of reflux esophagitis and its effects on clinical symptoms and life quality.METHODS:Totally 92 patients with reflux esophagitis admitted into this hospital from Sept.2019 to Sept.2020 were divided into two groups via the random number table.The control group(46 cases)was treated with Rabeprazole sodium enteric-coated capsules and Mosapride citrate dispersible tablets,while the observation group(46 cases)was given modified Buzhong Yiqi decoction based on the control group,both groups were continuously treated for 8 weeks.Changes of gastrointestinal hormone levels,oxidative stress indicators of esophageal mucosal tissue,TCM syndrome integrals and scores of life quality before and after 8 weeks of treatment in the two groups were observed,the clinical efficacy and incidences of adverse drug reactions were analyzed.RESULTS:The total effective rate of observation group was 95.65%(44/46),which was higher than that of the control group(80.43%,37/46),with statistically significant difference(P<0.05).Compared with before treatment,the serum motilin,gastrin and total superoxide dismutase of esophageal mucosal tissue in both groups were increased,the general score of short form 36 health survey,physical health score and mental health score were increased,the nitric oxide and malondialdehyde levels of esophageal mucosal tissue were decreased,various TCM syndrome integrals(chest distension,heat burn,hiccup singultation and emotion depression)were decreased;the above indicators and scores were significantly better in the observation group than in the control group,with statistically significant difference(P<0.05).The incidences of adverse drug reactions of observation group and control group were respectively 10.87%(5/46)and 8.70%(4/46),the difference was not statistically significant(P>0.05).CONCLUSIONS:The clinical efficacy of modi

关 键 词：补中益气汤加减 雷贝拉唑钠肠溶胶囊 枸橼酸莫沙必利分散片 反流性食管炎 临床症状 生活质量 

分 类 号：R932[医药卫生—生药学]