奥曲肽辅助止血治疗肝硬化上消化道出血患者的效果及对血清中氧化应激指标水平的影响  

Efficacy of octreotide auxiliary hemostasis on patients with cirrhosis complicated with upper gastrointestinal bleeding and its influence on serum levels of oxidative stress

作　　者：胡倩[1] 陈炅[1] 郭华[1] Hu Qian;ChenJiong;Guo Hua(Department of physical examination,the fifth affiliated hospital of Zhengzhou University,Zhengzhou,Henan,450000,China)

机构地区：[1]郑州大学第五附属医院体检科,河南郑州450000

出　　处：《齐齐哈尔医学院学报》2021年第23期2048-2051,共4页Journal of Qiqihar Medical University

摘　　要：目的探讨奥曲肽辅助止血治疗肝硬化上消化道出血患者的效果。方法选择2018年7月—2020年8月本院收治的79例肝硬化上消化道出血患者作为研究对象,按随机数表法分为对照组(40例)和观察组(39例)两组。对照组患者给予常规治疗,观察组患者在对照组基础上给予奥曲肽辅助止血治疗。观察两组治疗效果、氧化应激水平、凝血功能以及不良反应。结果治疗后,观察组患者总有效率(97.43%)高于对照组(82.50%),差异有统计学意义(P<0.05);观察组患者的超氧化物歧化酶(SOD)水平高于对照组,脂质过氧化氢(LHP)、丙二醛(MDA)水平均低于对照组,差异有统计学意义(P<0.05);观察组患者的纤维蛋白原(FIB)水平高于对照组,凝血酶时间(TT)、凝血酶原时间(PT)及活化部分凝血酶原时间(APTT)均水平均低于对照组,差异具有统计学意义(P<0.05);观察组患者的不良反应发生率(7.68%)与对照组(12.50%)比较差异无统计学意义(P>0.05)。结论奥曲肽辅助止血治疗肝硬化上消化道出血患者可调节凝血功能,改善氧化应激反应进而提高治疗效果,且不增加不良反应。Objective To explore the efficacy of octreotide assisted hemostasis in the treatment of upper gastrointestinal bleeding in patients with liver cirrhosis.Methods From July 2018 to August 2020,79 patients were admitted to our hospital due to liver cirrhosis and upper gastrointestinal bleeding were enrolled as study objects,and they were divided into a control group(40 patients)and observation group(39 patients)according to the random table method.Patients in the control group were given conventional treatment,while the patients in the observation group were given octreotide adjuvant therapy on the basis of the control group.The therapeutic effect,oxidative stress level,blood coagulation function and adverse reactions of the two groups were observed.Results After treatment,the total effective rate(97.43%)of the observation group was higher than that(82.50%)of the control group(P<0.05);the level of superoxide dismutase(SOD)in the observation group was higher than that of the control group,however,the levels of lipid hydrogen peroxide(LHP)and malondialdehyde(MDA)were lower than those of the control group(P<0.05);the level of fibrinogen(FIB)in the observation group was higher than that of the control group,but thrombin time(TT),prothrombin time(PT)and activated part prothrombin time(APTT)were shorter than the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the observation group(7.68%)and the control group(12.50%)(P>0.05).Conclusions Octreotide assisted hemostasis in the treatment of upper gastrointestinal bleeding in patients with liver cirrhosis could regulate blood coagulation,improve oxidative stress response and thus improve the therapeutic effect without increasing adverse reactions.

关 键 词：奥曲肽 肝硬化上消化道出血 氧化应激 凝血功能 

分 类 号：R657.3[医药卫生—外科学]