运动应激介导线粒体DAMP对先天性免疫的调控作用研究进展  

Research Progress in The Regulation of Mitochondrial DAMPs Mediated by Exercise Stress on Innate Immunity

作　　者：戈哲 丁树哲[2] GE Zhe;DING Shu-Zhe(School of Sport,Shenzhen University,Shenzhen 518060,China;Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China)

机构地区：[1]深圳大学体育学院,深圳518060 [2]华东师范大学青少年健康评价与运动干预教育部重点实验室,上海200241

出　　处：《生物化学与生物物理进展》2021年第12期1483-1492,共10页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(31671241);深圳大学运动心理教育协同创新研究一般项目资助。

摘　　要：线粒体是先天性免疫的关键调控者,具体表现为:线粒体可以通过释放多种线粒体损伤相关分子模式(damageassociated molecular patterns,DAMPs)来诱发先天性免疫应答,如线粒体DNA(mitochondrial DNA,mtDNA)、线粒体转录因子A(mitochondrial transcription factor A,TFAM)、线粒体N-甲酰肽(mitochondrial N-formyl peptides,F-MITs)、ATP等.然而,病毒也利用相应的机制抑制线粒体DAMPs诱导的先天性免疫.众所周知,适度的运动对机体免疫系统有着积极健康的影响,而大强度运动反之.再者,运动又与线粒体的关系密切.因此,运动很可能通过线粒体DAMPs的释放来调控先天性免疫.本文综述了线粒体DAMPs与先天性免疫的联系,并探讨了运动在其中所扮演的角色,以期从线粒体的视角为运动对先天性免疫的调控机制提供新的研究思路.Mitochondria play a pivotal role in innate immunity.Specifically,mitochondria can trigger innate immune response by releasing various damage associated molecular patterns(DAMPs),such as mitochondrial DNA(mtDNA),mitochondrial transcription factor A(TFAM),mitochondrial N-formyl peptides(F-MITs).However,the virus also uses a corresponding mechanism to suppress the innate immunity induced by mitochondrial DAMPs.It is well known that moderate exercise has a positive and healthy effect on the immune system,while high-intensity exercise has the opposite effect.Importantly,exercise is also intimately related to mitochondria.Thus,exercise is likely to regulate innate immunity through the release of mitochondria DAMPs.This paper reviews the link between mitochondrial DAMPs and innate immunity and explores the role of exercise in it,so as to provide new research ideas for the regulation mechanism of exercise on innate immunity from the perspective of mitochondria.

关 键 词：mtDNA 先天性免疫 Toll样受体9 线粒体外膜移位酶70 环鸟苷酸-腺苷酸合成酶-干扰素基因刺激蛋白 线粒体抗病毒信号蛋白 

分 类 号：Q28[生物学—细胞生物学]