Synthesis of aminoisoquinolines via Rh-catalyzed[4+2]annulation of benzamidamides with vinylene carbonate  

作　　者：Xin Huang Yingying Xu Jianglian Li Ruizhi Lai Yi Luo Qiantao Wang Zhongzhen Yang Yong Wu 

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2021年第11期3518-3521,共4页中国化学快报（英文版）

基　　金：the support from the National Natural Science Foundation of China(NSFC,Nos.81602954,81573286,81373259 and 81773577).

摘　　要：A new strategy is developed for the synthesis of 1-aminoisoquinoline derivatives.This Rh(III)-catalyzed[4+2]annulation reaction employs benzamidines as efficient directing groups and the vinylene carbonate as an acetylene surrogate.Additionally,the reaction features broad substrate scopes and good yields,only producing carbonate anion as byproduct.

关 键 词：Benzamidamide Aminoisoquinolines Vinylene carbonate C-H Activation Rh-catalyzed 

分 类 号：O626.323[理学—有机化学] TQ460.1[理学—化学]