云芝五味子浸膏对小鼠急性酒精肝损伤的保护作用  

Protective Effect of Extracts of Coriolus versicolor-Schisandra chinensis on Acute Alcoholic-induced Liver Injury in Mice

作　　者：冯耀培 郑斯文[1] 郑培和[1] 曲正义[1] 周春元[1] 宋慧[3] 王英平[1,2] FENG Yaopei;ZHENG Siwen;ZHENG Peihe;QU Zhengyi;ZHOU Chunyuan;SONG Hui;WANG Yingping(Institute of Special Animal and Plant Sciences,Chinese Academy of Agricultural Sciences,Changchun 130112,China;College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China;College of Life Sciences,Jilin Agricultural University,Changchun 130118,China)

机构地区：[1]中国农业科学院特产研究所,长春130112 [2]吉林农业大学中药材学院,长春130118 [3]吉林农业大学生命科学学院,长春130118

出　　处：《吉林农业大学学报》2021年第6期690-696,共7页Journal of Jilin Agricultural University

基　　金：吉林省省级医药健康产业发展专项(20170311053YY)。

摘　　要：为探讨云芝五味子浸膏(CSE)对急性酒精肝损伤的保护作用。以ICR小鼠为试验动物建立急性酒精肝损伤模型。通过H&E染色观察肝脏病理变化,并且分别以血清中ALT、AST、MDA、TG、T-CHO、LDL-C及HDL-C水平,肝组织中SOD、CAT、GSH-Px及MDA水平变化,来研究CSE对小鼠急性酒精肝损伤的保护作用。结果表明:CSE能够显著改善酒精造成的肝脏细胞脱落、脂肪变性,能够有效改善氧化应激,降低血清ALT、AST活力及MDA、TG、T-CHO和LDL-C含量,提高HDL-C含量;同时,降低肝组织MDA含量,提高SOD、GSH-Px、CAT活力。这说明CSE可以缓解酒精造成的急性酒精性肝损伤,且中剂量效果最优。The study was aimed to investigate the protective effect of the extracts of Coriolus versicolor-Schisandra chinensis(CSE)on acute alcoholic-induced liver injury in mice.The acute alcoholic-induced liver injury model of ICR mice was established.The liver pathological changes were observed by H&E staining.The protective effects of CSE on acute alcoholic-induced liver injury in mice were determined by the levels of ALT,AST,MDA,TG,T-CHO,LDL-C and HDL-C in serum,SOD,CAT,GSH-Px and MDA in liver tissue.The results showed that CSE could significantly improve liver cell exfoliation and fatty degeneration caused by alcohol.Moreover,CSE could effectively improve oxidative stress in mice,which decreased the activities of ALT,AST and the content of MDA,TG,T-CHO and LDL-C,and increased the content of HDL-C in serum;at the same time,CSE decreased the content of MDA and increased the activities of SOD,GSH-Px and CAT in liver tissue.This indicated that CSE can alleviate the acute alcoholic-induced liver injury,and the medium dose groups are the best.

关 键 词：云芝 五味子 酒精性肝损伤 保护作用 

分 类 号：S567.19[农业科学—中草药栽培] S646.2[农业科学—作物学]