柴胡加龙骨牡蛎汤结合耳穴贴压在治疗便秘型肠易激综合征中的应用研究  

Study on Chaihu Plus Longgu Muli Decoction combined with auricular-plaster therapy in the treatment of irritable bowel syndrome with constipation

作　　者：潘婧 窦欣 杜梦斐 黄秀杰[1] PAN Jing;DOU Xin;DU Mengfei;HUANG Xiujie(Department of Traditional Chinese Medicine,Central People’s Hospital of Zhanjiang,Guangdong,Zhanjiang 524000,China;Department of Dermatology,Central People’s Hospital of Zhanjiang,Guangdong,Zhanjiang 524000,China)

机构地区：[1]广东省湛江中心人民医院中医科,广东湛江524000 [2]广东省湛江中心人民医院皮肤科,广东湛江524000

出　　处：《中国医药科学》2022年第1期8-11,共4页China Medicine And Pharmacy

基　　金：广东省中医药局科研项目(20191387)。

摘　　要：目的研究柴胡加龙骨牡蛎汤结合耳穴贴压治疗便秘型肠易激综合征(IBS-C)的临床效果。方法选取2019年1月至2020年9月湛江中心人民医院中医科收治的60例便秘型肠易激综合征患者为研究对象,按随机数字表法分为对照组及观察组,每组各30例。对照组采用口服地衣芽孢杆菌活菌颗粒治疗,观察组采用柴胡加龙骨牡蛎汤结合耳穴贴压治疗,疗程为1个月。治疗1个月后观察比较两组患者治疗前后胃肠激素水平、便秘与腹痛的临床症状变化,停药1个月后随访临床症状疗效。结果治疗1个月后,两组胃动素、血管活性肠肽、生长抑素水平较治疗前均有明显改善,差异有统计学意义(P<0.05);观察组血管活性肠肽、生长抑素水平均低于对照组,差异有统计学意义(P<0.05),观察组胃动素水平高于对照组,差异有统计学意义(P<0.05)。两组患者腹痛积分均有所降低,且观察组积分明显低于对照组,差异有统计学意义(P<0.05);两组患者便秘情况均有效改善,且观察组积分低于对照组,差异有统计学意义(P<0.05)。治疗1个月后,观察组有6例治愈、22例好转,对照组有2例治愈、18例好转,观察组总治愈率为93.33%,明显高于对照组的66.67%,差异有统计学意义(P<0.05)。结论在IBS-C临床治疗上,柴胡加龙骨牡蛎汤结合耳穴贴压有较理想的临床治疗效果,值得推广和应用。Objective To study the clinical effect of Chaihu Plus Longgu Muli Decoction combined with auricular-plaster therapy on irritable bowel syndrome with constipation(IBS-C).Methods A total of 60 patients with IBS-C admitted to the Department of Traditional Chinese Medicine of Central People’s Hospital of Zhanjiang from January 2019 to September 2020 were selected as research objects,and they were randomly divided into the control group and the observation group,with 30 cases in each group.The control group was treated with oral Bacillus licheniformis granules,and the observation group was treated with Chaihu Plus Longgu Muli Decoction combined with auricular-plaster therapy,the course of treatment was 1 month.After one month of treatment,the changes of gastrointestinal hormone levels,clinical symptoms of constipation and abdominal pain were observed and compared between the two groups before and after treatment,and the curative effect during follow-up after one month of drug withdrawal was recorded.Results After one month of treatment,the levels of motilin,vasoactive intestinal peptide and somatostatin in the two groups were significantly improved compared with those before treatment,with statistically significant differences(P<0.05).The levels of vasoactive intestinal peptide and somatostatin in observation group were lower than those in control group,with statistically significant differences(P<0.05),and the level of motilin in observation group was higher than that in control group,with statistically significant difference(P<0.05).The abdominal pain scores of the two groups decreased,and the scores of the observation group were significantly lower than those of the control group,with statistically significant difference(P<0.05).Constipation was improved effectively,and the score of observation group was lower than that of control group,with statistically significant difference(P<0.05).After one month of treatment,6 cases were cured and 22 cases improved in the observation group.In the control group,2 cases were

关 键 词：柴胡加龙骨牡蛎汤 耳穴贴压 便秘 肠易激综合征 

分 类 号：R259[医药卫生—中西医结合]