保留动脉的显微精索静脉结扎术联合地奥司明治疗精索静脉曲张致少弱精子症的临床效果  

Clinical effect of artery-preserving microsurgical varicocelectomy combined with diosmin on oligospermia caused by varicocele

作　　者：郝维平 林天旗[1] 苏陈强 许振强[1] HAO Weiping;LIN Tianqi;SU Chenqiang;XU Zhenqiang(Department of Urology,Zhangzhou Municipal Hospital of Fujian Province,Fujian,Zhangzhou 363000,China)

机构地区：[1]福建省漳州市医院泌尿外科,福建漳州363000

出　　处：《中国医药科学》2022年第1期183-185,189,共4页China Medicine And Pharmacy

摘　　要：目的研究保留动脉的显微精索静脉结扎术联合地奥司明治疗精索静脉曲张(VC)致少弱精子症的临床效果。方法选取2020年1—12月福建省漳州市医院收治的80例VC致少弱精子症患者进行研究,采用随机抽签法分为对照组和干预组,每组各40例,对照组采用显微精索静脉结扎手术进行治疗,干预组基于显微精索静脉结扎手术基础上联合地奥司明进行治疗,比较两组的治疗效果、精索静脉的最大内径变化及精液质量。结果干预组治疗总有效率为97.50%,高于对照组的85.00%,差异有统计学意义(P<0.05);干预组治疗后精索静脉最大内径为(1.36±0.11)mm,小于对照组的(1.87±0.25)mm,差异有统计学意义(P<0.05);干预组治疗后精子浓度为(35.47±3.69)×10^(6)个/ml、前向运动精子占比(43.84±2.96)%及正常形态精子占比(4.23±0.94)%均高于对照组的(29.22±3.51)×10^(6)个/ml、(37.39±2.85)%、(3.79±0.91)%,差异有统计学意义(P<0.05)。结论保留动脉的显微精索静脉结扎术联合地奥司明治疗VC致少弱精子症的临床效果显著,能缩小精索静脉的最大内径,改善曲张症状,提升精液质量,值得推广应用。Objective To study the clinical effect of artery-preserving microsurgical varicocelectomy combined with diosmin in the treatment of oligospermia caused by varicocele(VC).Methods A total of 80 patients with oligospermia caused by VC admitted to Zhangzhou Municipal Hospital of Fujian Province from January 2020 to December 2020 were selected as research objects.They were randomly divided into control group and intervention group,with 40 patients in each group.The control group was treated with microsurgical varicocelectomy,while the intervention group was treated with diosmin based on microsurgical varicocelectomy.The efficacy,maximum inner diameter change of spermatic vein and semen quality of were compared between the two groups.Results The total effective rate of treatment in the intervention group was 97.50%,higher than that of the control group(85.00%),with statistically significant difference(P<0.05).The maximum inner diameter of spermatic vein in the intervention group was(1.36±0.11)mm,smaller than that in the control group([1.87±0.25]mm),and the difference was statistically significant(P<0.05).After treatment,the sperm concentration(35.47±3.69)×10^(6)/ml,the percentage of sperm move forward(43.84±2.96)%and normal sperm percentage(4.23±0.94)%in the intervention group were higher than those in the control group([29.22±3.51]×10^(6)/ml,[37.39±2.85]%,and[3.79±0.91]%,respectively),with statistically significant differences(P<0.05).Conclusion The artery-preserving microsurgical varicocelectomy combined with diosmin is effective in treating oligospermia caused by VC,which can reduce the maximum inner diameter of spermatic vein,improve varicose symptoms and improve semen quality,and is worthy of popularization and application.

关 键 词：保留动脉 显微精索静脉结扎术 地奥司明 精索静脉曲张 少弱精子症 

分 类 号：R651[医药卫生—外科学] R741[医药卫生—临床医学]