拉贝洛尔联合硫酸镁治疗重症妊娠期高血压的临床效果及对患者血清LIF、Apelin和Hcy水平的影响  

Clinical effect of labetalol combined with magnesium sulfate in the treatment of severe pregnancy induced hypertension and its influence on the levels of serum LIF,Apelin and Hcy

作　　者：苏晓丽[1] 佀小爱 SU Xiaoli;SI Xiao'ai(Obstetrics and Gynecology Department,Hancheng People's Hospital,Weinan 715400;Obstetrics and Gynecology Department,the Hospital of Fuping County,Weinan 711700,China)

机构地区：[1]韩城市人民医院妇产科,陕西渭南715400 [2]富平县医院妇产科,陕西渭南711700

出　　处：《临床医学研究与实践》2022年第2期120-123,共4页Clinical Research and Practice

摘　　要：目的观察拉贝洛尔联合硫酸镁治疗重症妊娠期高血压的临床效果及对患者血清白血病抑制因子(LIF)、Apelin、同型半胱氨酸(Hcy)水平的影响。方法选取2018年6月至2019年12月我院收治的96例重症妊娠期高血压患者为研究对象,采用随机数字表法将其分为对照组和观察组,各48例。对照组给予硫酸镁治疗,观察组在对照组基础上给予拉贝洛尔治疗。比较两组患者的临床疗效、舒张压、收缩压、血清LIF、Apelin、Hcy水平变化情况、妊娠不良事件发生情况和不良反应发生情况。结果观察组的治疗总有效率为93.75%,显著高于对照组的72.92%(P<0.05)。治疗后,两组的舒张压、收缩压均较治疗前显著降低,且观察组明显低于对照组(P<0.05)。治疗后,两组的LIF、Apelin水平明显提高,Hcy水平明显降低,且观察组的血清LIF、Apelin水平明显高于对照组,Hcy水平明显低于对照组(P<0.05)。观察组的妊娠不良事件总发生率明显低于对照组,差异具有统计学意义(P<0.05)。两组治疗期间的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论拉贝洛尔联合硫酸镁治疗重症妊娠期高血压患者能够提高临床效果,明显改善患者血压、炎性状态和妊娠结局,安全性高。Objective To observe the clinical effect of labetalol combined with magnesium sulfate in the treatment of severe pregnancy induced hypertension and its influence on the levels of serum leukemia inhibitory factor(LIF),Apelin and homocysteine(Hcy).Methods A total of 96 patients with severe pregnancy induced hypertension treated in our hospital from June 2018 to December 2019 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 48 cases in each group.The control group were treated with magnesium sulfate,and the observation group was treated with labetalol on the basis of the control group.The clinical efficacy,changes of diastolic blood pressure,systolic blood pressure,serum LIF,Apelin and Hcy levels,occurrence of adverse pregnancy events and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.75%,which was significantly higher than 72.92%in the control group(P<0.05).After treatment,the diastolic blood pressure and systolic blood pressure in the two groups were significantly lower than those before treatment,and those in the observation group were significantly lower than the control group(P<0.05).After treatment,the LIF and Apelin levels in the two groups increased significantly,and the Hcy level decreased significantly,and the LIF and Apelin levels in the observation group were significantly higher than those in the control group,the Hcy level was significantly lower than that in the control group(P<0.05).The total incidence of adverse pregnancy events in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions during treatment between the two groups(P>0.05).Conclusion Labetalol combined with magnesium sulfate in the treatment of patients with severe pregnancy induced hypertension can improve th

关 键 词：重症妊娠期高血压 拉贝洛尔 硫酸镁 

分 类 号：R714.24[医药卫生—妇产科学]