醋酸铜催化硝基芳烃的还原甲酰化:一种简便价廉的甲酰胺合成策略  

Copper Acetate Catalyzed Reduction and N-Formylation of Nitroarenes:A Simple and Inexpensive Approach for Synthesis of Formamide

作　　者：张红彦 杨孟芝 姜春勇 蔡小华[1] ZHANG Hong-Yan;YANG Meng-Zhi;JIANG Chun-Yong;CAI Xiao-Hua(School of Chemical Engineering,Guizhou Minzu University,Guiyang 550025,China;School of Ethnic-Minority Medicine,Guizhou Minzu University,Guiyang 550025,China)

机构地区：[1]贵州民族大学化学工程学院,贵阳550025 [2]贵州民族大学民族医药学院,贵阳550025

出　　处：《应用化学》2021年第12期1632-1638,共7页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(No.51863004);贵州省科学计划项目(No.[2018]1007);贵州省大学生创新与创业项目(No.201710672015)资助。

摘　　要：甲酰胺是合成药物、染料、香料及其它功能化学品的重要中间体和合成试剂,发展简单、绿色和经济的甲酰胺合成策略引起合成化学和工业领域的广泛关注。本文研究了以醋酸铜为催化剂,在甲酸-乙酸铵缓冲体系中,一锅法直接还原和N-甲酰化硝基芳烃合成甲酰胺的方法。该工艺提供了一种简便、经济的途径合成各种甲酰胺类化合物的方法,在优化的条件下,产物的最高收率可达到91%,催化剂循环使用5次后,产物的收率为77%,几乎没有活性降低。Formamide is an important intermediate for the preparation of drugs,dyes,perfumes and other functional chemicals and synthetic reagents,and the development of simple,green and economic strategy for the synthesis of formamides has always attracted extensive attention in the field of synthetic chemistry and industry.In this paper,a copper acetate catalyzed strategy for the formation of formamides through one-pot direct reduction and N-formylation of nitroarenes in a formic acid-ammonium acetate buffer system has been developed.This approach provides a simple and inexpensive strategy access to various formamides with up to 91%yields under optimal conditions.The yield of the product is 77%and there is no loss of the catalyst activity when it is recycled for five times.

关 键 词：甲酰胺 N-甲酰化 硝基芳烃 铜催化 甲酸-乙酸铵缓冲体系 

分 类 号：O626[理学—有机化学]