两种功能化环状赖氨酸单体的合成  

Synthesis of Two Functional Cyclic Lysine Monomers

作　　者：张帅 陶友华[1,2] ZHANG Shuai;TAO You-Hua(Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China)

机构地区：[1]中国科学院长春应用化学研究所,中国科学院生态环境高分子材料重点实验室,长春130022 [2]中国科学技术大学应用化学与工程学院,合肥230026

出　　处：《应用化学》2021年第12期1676-1678,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金项目(No.21805272)。

摘　　要：以赖氨酸为原料合成了胍基和季铵盐功能化的环状赖氨酸单体。单体的提纯和分离过程简单,产率在60%~80%之间。通过核磁共振波谱仪(NMR)和质谱(MS)等表征手段确认了功能化单体的结构。两种新型单体丰富了功能化环状赖氨酸单体的种类,也有望通过开环聚合来获得胍基和季铵盐功能化的聚氨基酸,具有广阔的应用前景。Using cyclic lysine as the starting material,two new monomers,namely guanidyl-and quaternary ammonium-functionalized cyclic lysine monomers are successfully synthesized via simple chemical reactions.Nuclear magnetic resonance spectroscopy(NMR)and mass spectrometry(MS)results confirm the monomers′structures.These two new monomers enrich the types of functional cyclic lysine monomers and are expected to be used to synthesize functionalized poly(amino acid)s with excellent antibacterial properties.

关 键 词：功能化环状赖氨酸 聚氨基酸 胍基 季铵盐 

分 类 号：O626[理学—有机化学]