PDMS-BG-TiO_(2)有机无机生物杂化材料的制备和性能研究  

Preparation and properties of titanium dioxide-enhanced PDMS-BG organic-inorganic biological hybrid materials

作　　者：陈茎 薛敏[1] 李学坤 石奇[1] 李蓓蓓 CHEN Jing;XUE Min;LI Xue-kun;SHI Qi;LI Bei-bei(School of Chemical Engineering,Xi'an University,Xi'an 710065,China)

机构地区：[1]西安文理学院,陕西西安710065

出　　处：《化学工程师》2021年第12期1-5,共5页Chemical Engineer

基　　金：陕西省自然科学基础研究计划项目(2019JM-520,2020JQ-890);西安市科技计划项目(2017CG WL23,2017CGWL26,2017CGWL27,2017CGWL28)。

摘　　要：具有良好生物活性的有机无机杂化材料已成为生物材料科学领域的重点研究内容。本题目以聚二甲基硅氧烷(PDMS)为改性剂,采用溶胶-凝胶法制备基于生物活性玻璃(PDMS-BG)的有机-无机杂化生物活性材料(PDMS-BG-TiO_(2)),研究了加入不同配比的正硅酸乙酯(TEOS)与异丙醇钛溶液(TIPT)对有机无机杂化材料成型能力和生物活性的影响。研究表明:与未在体液培养的试样相比,将试样在模拟体液SBF培养3d后,由试样的SEM图、XRD图和FTIR图谱可得这些材料均具有较好的生物矿化能力,当正硅酸乙酯∶异丙醇钛为12∶1时,制备的薄膜材料不易发生断裂,并且生物矿化能力表现得更为突出。这种有机无机杂化生物活性材料(PDMS-BG-TiO_(2))可能用做骨替代或者骨修复等生物材料。Crack-free organic-inorganic hybrid monoliths have a significant role for super-efficient bone tissue regeneration.The organic-inorganic hybrid material of PDMS-BG-TiO_(2) was formed through poly(dimethylsiloxane)as modifier via a sol-gel method.In this thesis,tetraisopropyltitanate(TiPT,Ti(OCH(CH_(3))_(2))_(4))was added to improve its forming ability and biomineralization ability.Results indicated that PDMS-BG and TIPT could be hybridized at a molecular level,and effects of the different proportions of ethyl orthosilicate and titanium isopropoxide on the structure and biomineralization activity of the as-prepared hybrid monoliths were also studied carefully.It is showed that the ratio of ethyl orthosilicate and titanium isopropoxide with 12∶1 can seriously prevent the formation of cracks and intensify the gelation of the hybrid monoliths,the hybrid monolith indicate negligible biomineralization ability in simulated body fluid(SBF)for 3 days.This organic-inorganic hybrid bioactive material(PDMS-BG-TiO_(2))may be used as a biological material such as bone replacement or bone repair.

关 键 词：生物活性玻璃 溶胶-凝胶法 有机-无机杂化材料 生物活性 

分 类 号：Q819[生物学—生物工程]