胺碘酮联合美托洛尔治疗老年冠心病并发心律失常患者的效果  

The effect of amiodarone combined with metoprolol in the treatment of elderly patients with coronary heart disease and arrhythmia

作　　者：毕成 BI Cheng(Tieling County Central Hospital,Tieling 112608,China)

机构地区：[1]铁岭县中心医院,112608

出　　处：《中国实用医药》2022年第3期119-121,共3页China Practical Medicine

摘　　要：目的探析胺碘酮联合美托洛尔治疗老年冠心病并发心律失常患者的效果。方法60例老年冠心病并发心律失常患者,按照治疗方案不同分为联合组与单纯组,各30例。单纯组采用胺碘酮治疗,联合组采用胺碘酮联合美托洛尔治疗。对比两组临床疗效、各项临床指标、不良反应发生率。结果联合组治疗总有效率为90.00%(27/30),高于单纯组的66.67%(20/30),差异有统计学意义(P<0.05)。治疗后,两组心率、QT离散度(QTd)水平均低于治疗前,且联合组心率(71.27±2.23)次/min、QTd(47.48±5.62)ms低于单纯组的(83.29±2.14)次/min、(56.22±6.28)ms,差异有统计学意义(P<0.05)。联合组不良反应发生率为6.67%(2/30),低于单纯组的26.67%(8/30),差异有统计学意义(P<0.05)。结论老年冠心病并发心律失常患者采用胺碘酮联合美托洛尔治疗后,能获得较为良好的治疗疗效,不仅能有效地减轻患者的病症,改善心率与QTd水平,同时还能降低不良反应发生率,值得临床应用。Objective To discuss and analyze the effect of amiodarone combined with metoprolol in the treatment of elderly patients with coronary heart disease and arrhythmia.Methods A total of 60 elderly patients with coronary heart disease and arrhythmia were divided into combined group and simple group according to different treatment plans,with 30 cases in each group.The simple group was treated with amiodarone,and the combined group was treated with amiodarone and metoprolol.The clinical efficacy,various clinical indicators,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the combined group was 90.00%(27/30),which was higher than 66.67%(20/30)in the simple group,and the difference was statistically significant(P<0.05).After treatment,the heart rate and QT dispersion(QTd)levels of the two groups were lower than those of this group before treatment,and the heart rate(71.27±2.23)beats/min and QTd(47.48±5.62)ms of the combined group were lower than(83.29±2.14)beats/min and(56.22±6.28)ms of the simple group.All the differences were statistically significant(P<0.05).The incidence of adverse reactions in the combined group was 6.67%(2/30),which was lower than 26.67%(8/30)in the simple group,and the difference was statistically significant(P<0.05).Conclusion Amiodarone combined with metoprolol can get a better therapeutic effect in elderly patients with coronary heart disease and arrhythmia.It can not only effectively reduce the patients'symptom,improve the heart rate and QTd level,but also reduce the incidence of adverse reactions,which is worthy of clinical application.

关 键 词：胺碘酮 美托洛尔 老年冠心病 心律失常 

分 类 号：R541.7[医药卫生—心血管疾病] R541.4[医药卫生—内科学]