小儿急性病毒性心肌炎予以磷酸肌酸钠治疗的有效性探究  

Efficacy of creatine phosphate sodium in the treatment of children with acute viral myocarditis

作　　者：毛林林 MAO Lin-lin(Fushun Hospital of Traditional Chinese Medicine,Fushun 113000,China)

机构地区：[1]抚顺市中医院,113000

出　　处：《中国实用医药》2022年第3期124-126,共3页China Practical Medicine

摘　　要：目的探讨小儿急性病毒性心肌炎予以磷酸肌酸钠治疗的有效性。方法100例小儿急性病毒性心肌炎患儿,根据随机数字表法分为磷酸肌酸钠组和对照组,每组50例。磷酸肌酸钠组患儿采用磷酸肌酸钠治疗;对照组患儿采用1,6-二磷酸果糖治疗。对比两组患儿治疗前后心肌酶谱指标(肌钙蛋白I、肌酸激酶、乳酸脱氢酶、肌酸激酶同工酶)、左心室射血分数、二尖瓣口舒张早期血流速度与舒张晚期血流速度比值(E/A)和治疗效果。结果治疗后,两组患儿肌钙蛋白I、肌酸激酶、乳酸脱氢酶、肌酸激酶同工酶水平低于本组治疗前,左心室射血分数、E/A高于本组治疗前,且磷酸肌酸钠组患儿肌钙蛋白I(0.12±0.05)μg/L、肌酸激酶(215.56±67.12)U/L、乳酸脱氢酶(256.63±88.12)U/L、肌酸激酶同工酶(26.12±2.56)U/L显著低于对照组的(0.71±0.12)μg/L、(544.51±144.21)U/L、(479.56±111.01)U/L、(52.13±14.21)U/L,左心室射血分数(53.12±5.56)%、E/A(1.28±0.23)高于对照组的(48.12±5.12)%、(1.01±0.19),差异具有统计学意义(P<0.05)。磷酸肌酸钠组患儿治疗总有效率为98.00%,高于对照组的78.00%,差异具有统计学意义(P<0.05)。结论磷酸肌酸钠在小儿急性病毒性心肌炎治疗中的应用价值高,能改善心肌功能指标,减少心肌损害,值得推广使用。Objective To discuss the efficacy of creatine phosphate sodium in the treatment of children with acute viral myocarditis.Methods 100 children with acute viral myocarditis were randomly divided into creatine phosphate sodium group and control group,with 50 cases in each group.Children in the creatine phosphate sodium group were administered with creatine phosphate sodium,while children in the control group were administered with fructose 1,6-diphosphate.The myocardial zymogram indicators(troponin I,creatine kinase,lactate dehydrogenase,creatine kinase isozyme),left ventricular ejection fraction,the ratio of early diastolic blood flow velocity to late diastolic blood flow velocity(E/A)before and after the treatment,and the therapeutic efficacy were compared between the two groups.Results After the treatment,the levels of troponin I,creatine kinase,lactate dehydrogenase and creatine kinase isozyme of each group were lower than those before the treatment,while the left ventricular ejection fraction and E/A of each group were higher than those before the treatment.The creatine phosphate sodium group had troponin I of(0.12±0.05)μg/L,creatine kinase of(215.56±67.12)U/L,lactate dehydrogenase of(256.63±88.12)U/L,creatine kinase isoenzyme of(26.12±2.56)U/L,which were significantly lower than(0.71±0.12)μg/L,(544.51±144.21)U/L,(479.56±111.01)U/L,(52.13±14.21)U/L of the control group,respectively;the creatine phosphate sodium group had left ventricular ejection fraction of(53.12±5.56)%,E/A of(1.28±0.23),which were significantly higher than(48.12±5.12)%,(1.01±0.19)of the control group,respectively;and the differences were statistically significant(P<0.05).The overall efficacy of the creatine phosphate sodium group was 98.00%,which was significantly higher than 78.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion The application value of creatine phosphate sodium in children with acute viral myocarditis is high,which can improve the indicators of myocardial function and re

关 键 词：小儿急性病毒性心肌炎 磷酸肌酸钠 心肌功能 有效性 

分 类 号：R725.4[医药卫生—儿科]