地西泮联合苯巴比妥治疗小儿惊厥的效果及对患儿血清学指标的影响分析  

Effect analysis of diazepam combined with phenobarbital in the treatment of pediatric convulsions and its influence on the serological indicators of children

作　　者：杨帆 YANG Fan(Department of Neonatology,Panjin Central Hospital,Panjin 124000,China)

机构地区：[1]辽宁省盘锦市中心医院妇产院区新生儿科,124000

出　　处：《中国实用医药》2022年第3期150-152,共3页China Practical Medicine

摘　　要：目的分析地西泮联合苯巴比妥治疗小儿惊厥的效果及对患儿血清学指标的影响。方法80例小儿惊厥患儿,随机分为对照组及观察组,各40例。对照组患儿采用苯巴比妥治疗,观察组患儿在对照组基础上增加地西泮治疗。比较两组惊厥发作控制时间、血清学指标恢复正常时间、住院时间、治疗前后血清学指标(脑源性神经营养因子、S-100β蛋白、神经元特异性烯醇化酶)水平、治疗效果、并发症发生情况及复发情况。结果观察组惊厥发作控制时间(8.26±1.28)h、血清学指标恢复正常时间(2.79±0.24)d、住院时间(6.29±1.02)d短于对照组的(10.12±2.21)h、(3.25±1.18)d、(8.15±2.18)d,差异有统计学意义(P<0.05)。治疗后,观察组脑源性神经营养因子、S-100β蛋白、神经元特异性烯醇化酶水平均低于对照组,差异有统计学意义(P<0.05)。观察组总有效率97.50%(39/40)高于对照组的77.50%(31/40),差异有统计学意义(P<0.05)。观察组并发症发生率2.50%(1/40)、复发率0低于对照组的15.00%(6/40)、12.50%(5/40),差异有统计学意义(P<0.05)。结论苯巴比妥与地西泮对于小儿惊厥的效果确切,可改善血清学指标,缩短治疗的时间,并减少并发症和复发情况。Objective To analyze the effect of diazepam combined with phenobarbital in the treatment of pediatric convulsions and its influence on the serological indicators of children.Methods A total of 80 cases of pediatric convulsions were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with phenobarbital,and the observation group was treated with diazepam on the basis of the control group.Both groups were compared in terms of time of convulsion control,recovery time of serum index,hospitalization time,serological indexes(brain-derived neurotrophic factor,S-100βprotein,neuron-specific enolase)levels before and after treatment,therapeutic effect,complications and recurrence.Results The time of convulsion control(8.26±1.28)h,recovery time of serum index(2.79±0.24)d,and hospitalization time(6.29±1.02)d of the observation group were shorter than(10.12±2.21)h,(3.25±1.18)d,(8.15±2.18)d of the control group,and the difference was statistically significant(P<0.05).After treatment,the brain-derived neurotrophic factor,S-100βprotein,and neuron-specific enolase levels of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).The total effective rate 97.50%(39/40)of the observation group was higher than 77.50%(31/40)of the control group,and the difference was statistically significant(P<0.05).The complication rate 2.50%(1/40)and recurrence rate 0 of the observation group were lower than 15.00%(6/40)and 12.50%(5/40)of the control group,and the difference was statistically significant(P<0.05).Conclusion Phenobarbital and diazepam have a definite effect on pediatric convulsions,which can improve serological indicators,shorten treatment time,and reduce complications and recurrence rates.

关 键 词：地西泮 苯巴比妥 小儿惊厥 效果 血清学指标 影响 

分 类 号：R720.597[医药卫生—急诊医学]