西咪替丁联合思密达治疗婴幼儿轮状病毒腹泻的临床疗效和安全性分析  

Clinical efficacy and safety analysis of cimetidine and Smecta in the treatment of infantile rotavirus diarrhea

作　　者：刘丹 LIU Dan(Department of Pharmacy,Shenyang Women and Infant Hospital,Shenyang 110014,China)

机构地区：[1]沈阳市妇婴医院药剂科,110014

出　　处：《中国现代药物应用》2022年第3期155-157,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究西咪替丁联合蒙脱石散(商品名:思密达)应用于婴幼儿轮状病毒腹泻患儿中的效果和安全性。方法180例婴幼儿轮状病毒腹泻,依据随机化分组法分为对照组和观察组,每组90例。对照组施予常规性治疗,观察组施予西咪替丁联合思密达治疗。比较两组临床症状消退时间、临床疗效、不良反应发生情况。结果观察组发热、呕吐、腹泻消退时间分别为(1.96±0.10)、(2.26±0.14)、(3.37±0.02)d,均短于对照组的(2.57±0.14)、(2.85±0.18)、(4.82±0.14)d,差异具有统计学意义(P<0.05)。观察组治疗总有效率为96.67%(87/90),高于对照组的87.78%(79/90),差异具有统计学意义(χ^(2)=4.957,P=0.026<0.05)。治疗后,观察组的不良反应发生率4.44%(4/90)低于对照组的13.33%(12/90),差异具有统计学意义(P<0.05)。结论婴幼儿轮状病毒腹泻治疗中应用西咪替丁联合思密达能够缩短患儿临床症状消退时间,并提升其治疗疗效,减少各类不良反应的发生,能够获得更为理想的效果,促进患儿康复,可推广。Objective To study the effect and safety of cimetidine and montmorillonite powder(trade name:Smecta)in the treatment of infantile rotavirus diarrhea.Methods A total of 180 infants with rotavirus diarrhea were divided into the control group and the observation group according to the randomization grouping method,with 90 cases in each group.The control group received conventional treatment,and the observation group received cimetidine combined with Smecta treatment.The subsidence time of clinical symptom,clinical efficacy,and occurrence of adverse reactions were compared between the two groups.Results The subsidence time of fever,vomiting,and diarrhea in the observation group were(1.96±0.10),(2.26±0.14),and(3.37±0.02)d,which were shorter than(2.57±0.14),(2.85±0.18),and(4.82±0.14)d in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 96.67%(87/90),which was higher than 87.78%(79/90)in the control group,and the difference was statistically significant(χ^(2)=4.957,P=0.026<0.05).After treatment,the incidence of adverse reactions 4.44%(4/90)in the observation group was lower than 13.33%(12/90)in the control group,and the difference was statistically significant(P<0.05).Conclusion Cimetidine combined with Smecta in the treatment of infantile rotavirus diarrhea can improve the subsidence time of clinical symptoms,improve the therapeutic effect,reduce the occurrence of various adverse reactions,which can obtain more ideal effect and promote the disease recovery,so it can be promoted.

关 键 词：婴幼儿轮状病毒腹泻 蒙脱石散 西咪替丁 

分 类 号：R725.1[医药卫生—儿科]