还原型谷胱甘肽联合甲巯咪唑治疗甲亢的疗效  

Efficacy of reduced glutathione combined with methimazole in the treatment of hyperthyroidism

作　　者：何娇 HE Jiao(Xinmin People’s Hospital,Xinmin 110300,China)

机构地区：[1]辽宁省新民市人民医院,110300

出　　处：《中国现代药物应用》2022年第3期179-181,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨甲状腺功能亢进症(甲亢)患者在治疗时应用还原型谷胱甘肽和甲巯咪唑进行联合治疗的临床疗效。方法50例甲亢患者,随机分为对照组及研究组,每组25例。对照组患者使用甲巯咪唑治疗,研究组患者使用还原型谷胱甘肽和甲巯咪唑联合治疗。比较两组治疗前后血清炎症因子水平、甲状腺指标水平以及治疗效、果不良反应发生情况。结果治疗后,两组患者白细胞介素-2(IL-2)、白细胞介素-6(IL-6)水平均较本组治疗前降低,且研究组患者IL-2、IL-6水平分别为(0.27±0.07)、(17.37±2.82)pg/ml,均低于对照组的(0.85±0.21)、(21.17±3.39)pg/ml,差异具有统计学意义(P<0.05)。治疗后,两组患者总三碘甲状腺原氨酸(TT_(3))、总甲状腺素(TT_(4))、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))均较本组治疗前降低,且研究组患者TT_(3)、TT_(4)、FT_(3)、FT_(4)低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率为96.00%(24/25),高于对照组的72.00%(18/25),差异具有统计学意义(P<0.05)。研究组患者不良反应发生率4.00%低于对照组的24.00%,差异具有统计学意义(P<0.05)。结论对于甲亢患者,应用还原型谷胱甘肽和甲巯咪唑进行联合治疗的疗效明显,安全可靠,有效缓解了临床症状,减少不良反应的发生,值得在临床上推广使用。Objective To discuss the clinical efficacy of reduced glutathione combined with methimazole in the treatment of hyperthyroidism.Methods A total of 50 patients with hyperthyroidism were randomly divided into control group and research group,with 25 cases in each group.Patients in the control group were treated with methimazole,and patients in the research group were treated with reduced glutathione and methimazole in combination.Both groups were compared in terms of the levels of serum inflammatory factors and thyroid indicators before and after treatment,therapeutic effects,and occurrence of adverse reactions.Results After treatment,the levels of interleukin-2(IL-2)and interleukin-6(IL-6)in the two groups were lower than those before treatment in this group;the levels of IL-2 and IL-6 in the research group were(0.27±0.07)and(17.37±2.82)pg/ml,which were lower than(0.85±0.21)and(21.17±3.39)pg/ml in the control group;all the differences were statistically significant(P<0.05).After treatment,the total triiodothyronine(TT_(3)),total thyroxine(TT_(4)),free triiodothyronine(FT_(3)),and free thyroxine(FT_(4))of the two groups were lower than those of this group before treatment,and the TT_(3),TT_(4),FT_(3),and FT_(4)of the research group were lower than those of the control group.All the differences were statistically significant(P<0.05).The total effective rate of treatment in the research group was 96.00%(24/25),which was higher than 72.00%(18/25)in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 4.00%in the research group was lower than 24.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion For hyperthyroidism patients,the combined treatment with reduced glutathione and methimazole is effective,safe and reliable,which can effectively alleviate clinical symptoms and reduce the occurrence of adverse reactions,which is worthy of promotion and application.

关 键 词：甲状腺功能亢进症 还原型谷胱甘肽 甲巯咪唑 联合治疗 临床疗效 

分 类 号：R581.1[医药卫生—内分泌]