奥美拉唑的核磁共振研究  

The Study of Nuclear Magnetic Resonance for Omeprazole

作　　者：王晓燕[1] 张春春 WANG Xiaoyan;ZHANG Chunchun(Analytical&Testing Center,Sichuan University,Chengdu 610064,China)

机构地区：[1]四川大学分析测试中心,成都610064

出　　处：《实验科学与技术》2022年第1期11-15,共5页Experiment Science and Technology

基　　金：四川大学实验技术立项项目(SCU201209)。

摘　　要：利用核磁共振技术(1H NMR,13C NMR)对奥美拉唑的溶液行为进行了研究,确定了该化合物在溶液中存在氮杂芳环的互变异构现象,而氮杂芳环的互变异构对核磁共振结果的影响异常明显,部分峰峰型改变,部分峰信号极弱。通过改变三种溶剂(氯仿、甲醇、二甲基亚砜)、检测温度(室温和80摄氏度)和不同当量的碱对样品体系和测试环境进行调制,提高了核磁共振谱图的质量。加碱破坏氢键后,分子结构中的氢原子和碳原子在氢谱和碳谱都出现对应的强信号,利于化合物的解析。The solution behavior of omeprazole was studied by 1 H NMR and 13 C NMR. It was confirmed that there was tautomerism of azaaryl ring in the solution. The tautomerism of azaaryl ring had an obvious effect on the NMR results, leading to peak shifts and signal strength. The quality of the NMR spectra was improved by adjusting the solvents(chloroform, methanol, dimethyl sulfoxide), temperatures(room temperature and 80 ℃) and amounts of alkali. By adding alkali to break the hydrogen bond, the hydrogen atom and carbon atom in the molecular structure have corresponding enhanced signals in 1 H NMR and 13 C NMR spectrum,which is conducive to the analysis of compounds.

关 键 词：奥美拉唑 核磁共振 互变异构 变温 溶剂效应 

分 类 号：O633[理学—高分子化学]