子痫前期患者甲功、血脂水平的相关性分析  

Analysis of Thyroid Function and Blood Lipid Level in Patients with Preeclampsia

作　　者：刘丽丽 朱启英[1] 李晶[1] LIU Li-li;ZHU Qi-ying;LI Jing(Department of Obstetrics in Maternal-Fetail Medical Center,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054)

机构地区：[1]新疆医科大学第一附属医院母胎医学中心产科,新疆乌鲁木齐830054

出　　处：《智慧健康》2021年第26期8-10,14,共4页Smart Healthcare

基　　金：新疆维吾尔自治区自然科学基金(项目编号:2016D01C278)。

摘　　要：目的探讨孕妇甲状腺功能、血脂水平与子痫前期的相关性。方法选取2019年1月至2020年12月在新疆医科大学第一附属医院母胎医学中心产科就诊的子痫前期孕妇共247例作为病例组,同期进行孕期检查的正常孕妇183例作为对照组,检测两组孕妇血清中的游离甲状腺激素3(FT3)、游离甲状腺激素4(FT4)、促甲状腺激素(TSH)、抗甲状腺球蛋白抗体(TGAB)、抗甲状腺过氧化物酶抗体(TPOAB)、甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平并进行应用Logistic回归分析,比较两组的变化情况。结果病例组孕妇的TSH、TG、TC、LDL-C水平高于对照组,FT3和FT4、HDL-C水平低于对照组,差异有统计学意义(P<0.05),且孕妇血清FT4、TC水平是子痫前期发生的独立危险因素(0R=1.138,P<0.05;0R=3.462,P<0.001),HDL-C水平是子痫前期发生的独立保护因素(OR=0.662,P<0.001);病例组TGAB、TPOAB与对照比较,差异无统计学意义(P>0.05)。结论孕妇低水平FT3、FT4和高水平TSH、TG、TC、LDL-C是子痫前期发病的危险因素,孕妇高水平的HDL-C是子痫前期发病的保护因素,且结果显示孕妇血清TC水平与子痫前期呈正相关,FT4、HDL-C水平与子痫前期呈负相关;可以为早期预测治疗子痫前期、改善母婴结局提供依据。Objective To investigate the correlation between thyroid function,blood lipid level and preeclampsia.Methods A total of 247 pregnant women with preeclampsia who visited the Department of Obstetrics in Maternal-Fetail Medical Center of the First Affiliated Hospital of Xinjiang Medical University from January 2019 to December 2020 were selected as the case group,and 183 normal pregnant women who received pregnancy examination during the same period were selected as the control group.FT3,FT4,TSH,TGAB,TPOAB,TG,TC,HDL-C,LDL-C levels in serum in the two groups were tested and Logistic regression analysis was applied to compare the changes in the two groups.Results The levels of TSH,TG,TC and LDL-C of pregnant women in the case group were higher than those in the control group,while the levels of FT3,FT4 and HDL-C were lower than those in the control group,with statistical significance(P<0.05).Serum FT4 and TC levels of pregnant women were independent risk factors for the occurrence of preeclampsia(OR=1.138,P<0.05;OR=3.462,P<0.001),HDL-C level was an independent protective factor for preeclampsia(OR=0.662,P<0.001).There was no significant difference in TGAB and TPOAB between the case group and the control group(P>0.05).Conclusion Low level FT3,FT4 and high level of TSH,TG,TC,LDL-C are risk factors for preeclampsia,high level HDL-C is protective factor for preeclampsia and the results showed that serum TC level was positively associated with preeclampsia and FT4,and HDL-C was negatively associated with preeclampsia,which can provide basis for early prediction and treatment of preeclampsia and improving maternal and infant outcome.

关 键 词：甲状腺功能 血脂 子痫前期 

分 类 号：R714.244[医药卫生—妇产科学]