Mild moxibustion plus loratadine tablets for children with allergic rhinitis:a randomized controlled trial  

温和灸联合氯雷他定治疗儿童变应性鼻炎:随机对照研究

作　　者：Li Yong Guo Xiao-qing 李勇;郭晓庆(Wuhan Hospital of Traditional Chinese Medicine,Hubei Province,Wuhan 430014,China)

机构地区：[1]Wuhan Hospital of Traditional Chinese Medicine,Hubei Province,Wuhan 430014,China

出　　处：《Journal of Acupuncture and Tuina Science》2021年第6期419-424,共6页针灸推拿医学（英文版）

摘　　要：Objective To explore the efficacy of mild moxibustion plus loratadine tablets for children with allergic rhinitis(AR).Methods A total of 80 children were randomized into a control group and an observation group,with 40 cases in each group.The control group was treated with loratadine tablets,and the observation group was treated with mild moxibustion plus loratadine tablets.Before and after treatment,the total nasal symptom score(TNSS)was evaluated,and the serum eosinophils(EOS)count,and the interleukin(IL)-27 and macrophage migration inhibitory factor(MIF)levels were measured.Clinical efficacy was evaluated after treatment.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the TNSS in both groups decreased(P<0.05),and the TNSS in the observation group was lower than that in the control group(P<0.05);the serum EOS count in both groups decreased(P<0.05),and the serum EOS count in the observation group was lower than that in the control group(P<0.05).The serum IL-27 level in the control group had no statistical difference compared with the same group before treatment(P>0.05),and the serum MIF level decreased after treatment(P<0.05).The serum IL-27 level in the observation group increased after treatment(P<0.05),and the serum MIF level decreased after treatment(P<0.05),and were both statistically different from those in the control group(P<0.05).Conclusion Mild moxibustion plus loratadine tablets is effective in treating children with AR.It can significantly improve the nasal symptoms and reduce the serum EOS count,which may be related to the regulation of the serum IL-27 and MIF levels.目的探讨温和灸联合氯雷他定治疗儿童变应性鼻炎(AR)的疗效。方法将80例患儿随机分为对照组和观察组,每组40例。对照组予氯雷他定治疗,观察组予温和灸联合氯雷他定治疗。治疗前后评定鼻部症状总评分(TNSS),测定血清嗜酸性粒细胞(EOS)计数及白介素(IL)-27和巨噬细胞移动抑制因子(MIF)水平。并在治疗后评价疗效。结果观察组有效率高于对照组(P<0.05);治疗后,两组TNSS总分均降低(P<0.05),观察组TNSS总分低于对照组(P<0.05);两组血清EOS计数均较治疗前降低(P<0.05),观察组血清EOS计数低于对照组(P<0.05);对照组血清IL-27水平与本组治疗前无统计学差异(P>0.05),血清MIF水平较本组治疗前降低(P<0.05),观察组血清IL-27水平较本组治疗前升高(P<0.05),血清MIF水平较治疗前降低(P<0.05),且均与对照组有统计学差异(P<0.05)。结论温和灸联合氯雷他定治疗儿童AR疗效确切,可显著改善患儿鼻部症状,降低血清EOS计数,这可能与其调节患儿血清IL-27和MIF水平有关。

关 键 词：Moxibustion Therapy Moxa Stick Moxibustion LORATADINE Rhinitis Allergic Randomized Controlled Trials CHILD 

分 类 号：R246.8[医药卫生—针灸推拿学]