雪旺细胞调控骨组织再生的研究进展  

Research progress of Schwann cells regulating bone regeneration

作　　者：王晓昱 张睿[1] 余轶凡 徐佳[1] 康庆林[1] WANG Xiaoyu;ZHANG Rui;YU Yifan;XU Jia;KANG Qinglin(Department of Orthopedics,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai,200233,P.R.China)

机构地区：[1]上海交通大学附属第六人民医院骨科,上海200233

出　　处：《中国修复重建外科杂志》2022年第2期236-241,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(82072421)。

摘　　要：目的对雪旺细胞调控骨组织再生的研究进展进行综述。方法广泛查阅国内外雪旺细胞对组织再生研究的相关文献,从雪旺细胞的骨再生作用、多样化促进组织再生能力、旁分泌神经因子网络的营养效应和其在骨组织工程学中的应用等多个方面进行总结分析。结果作为周围神经系统的组成部分,雪旺细胞通过旁分泌效应,调控多种神经营养因子和生长因子的表达,从而有效参与到了血管和骨骼等非神经组织的再生分化过程,体现了其具有神经-血管-骨整合的营养效应。结论充分利用雪旺细胞的神经、血管和骨骼组织多能化再生效应,可为组织工程骨的临床应用提供新思路。Objective To review the research progress on the role of Schwann cells in regulating bone regeneration. Methods The domestic and foreign literature about the behavior of Schwann cells related to bone regeneration, multiple tissue repair ability, nutritional effects of their neurotrophic factor network, and their application in bone tissue engineering was extensively reviewed. Results As a critical part of the peripheral nervous system, Schwann cells regulate the expression level of various neurotrophic factors and growth factors through the paracrine effect, and participates in the tissue regeneration and differentiation process of non-neural tissues such as blood vessels and bone,reflecting the nutritional effect of neural-vascular-bone integration. Conclusion Taking full advantage of the multipotent differentiation ability of Schwann cells in nerve, blood vessel, and bone tissue regeneration may provide novel insights for clinical application of tissue engineered bone.

关 键 词：雪旺细胞 骨再生 血管生成 神经营养因子 生长因子 骨组织工程 

分 类 号：R318[医药卫生—生物医学工程]