艾曲波帕联合环孢素A对再生障碍性贫血患者血清血小板生成素、粒细胞集落刺激因子及粒-巨噬细胞集落刺激因子的影响  

Effects of itropopa combined with cyclosporine A on serum thrombopoietin,granulocyte colony stimulating factor and granulocyte macrophage colony stimulating factor in patients with aplastic anemia

作　　者：杨讯[1] 杨旭[1] 许词 闫彬 YANG Xun;YANG Xu;XU Ci;YAN Bin(Department of Blood Transfusion,Nanyang Central Hospital,Nanyang 473005,Henan Province,China;Department of Laboratory Medicine,Nanyang Central Hospital,Nanyang 473005,Henan Province,China)

机构地区：[1]南阳市中心医院输血科,河南南阳473005 [2]南阳市中心医院检验科,河南南阳473005

出　　处：《世界临床药物》2021年第12期1108-1112,共5页World Clinical Drug

摘　　要：目的探讨艾曲波帕联合环孢素A对再生障碍性贫血(aplastic anemia,AA)患者血清血小板生成素(thrombopoietin,TPO)、粒细胞集落刺激因子(granulocyte colony stimulating factor,G-GSF)、粒-巨噬细胞集落刺激因子(granulocyte macrophage colony stimulating factor,GM-CSF)的影响。方法选择2018年1月至2020年8月于我院接受治疗的125例AA患者,采用随机数表法分为试验组(n=63)及对照组(n=62)。对照组给予环孢素A治疗,试验组给予艾曲波帕联合环孢素A治疗。比较两组临床疗效、血清TPO、G-GSF、GM-CSF、血小板计数(platelet count,PLT)、白细胞(white blood cell,WBC)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、分化簇(cluster of differentiation,CD)4^(+)、CD8^(+)水平变化情况及并发症发生情况。结果治疗后,试验组及对照组临床总有效率分别为93.65%、70.97%(P<0.05)。与治疗前相比,两组血清TPO、G-GSF、GM-CSF、血清血常规指标水平、免疫细胞水平差异无统计学意义(P>0.05)。治疗后,所有患者血清TPO、CD8^(+)均降低,且试验组低于对照组(P<0.05);G-GSF、GM-CSF、PLT、WBC、VEGF、CD4^(+)均升高,且试验组高于对照组(P<0.05)。治疗期间,两组并发症发生率比较差异无统计学意义(P>0.05)。结论AA患者联用艾曲波帕及环孢素A疗效显著,这可能与艾曲波帕及环孢素A可有效改善TPO、G-GSF、GM-CSF水平有关。Objective To investigate the effects of itropopa combined with cyclosporine A on serum thrombopoietin(TPO),granulocyte colony stimulating factor(G-GSF)and granulocyte macrophage colony stimulating factor(GM-CSF)in patients with aplastic anemia(AA).Methods A total of 125 AA patients treated in our hospital from January 2018 to August 2020 were randomly divided into experimental group(n=63)and control group(n=62).The control group was treated with cyclosporine A,and the experimental group was treated with itropopa combined with cyclosporine A.The clinical efficacy,changes of serum TPO,G-GSF,GM-CSF,platelet count(PLT),white blood cell(WBC),vascular endothelial growth factor(VEGF),cluster of differentiation(CD)4^(+),CD8^(+)and complications were compared between the two groups.Results After treatment,the total clinical effective rates of the experimental group and the control group were 93.65%and 70.97%respectively(P<0.05).Compared with before treatment,there was no significant difference in serum TPO,G-GSF,GM-CSF,serum blood routine index level and immune cell level between the two groups(P>0.05).After treatment,the levels of serum TPO and CD8^(+)in the experimental group were lower than those in the control group(P<0.05).The levels of G-GSF,GM-CSF,PLT,WBC,VEGF and CD4^(+)in the experimental group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups during treatment(P>0.05).Conclusion The combination of itropopa and cyclosporine A is effective in AA patients,which may be related to the fact that itropopa and cyclosporine A can effectively improve the levels of TPO,G-GSF and GM-CSF.

关 键 词：艾曲波帕 环孢素A 再生障碍性贫血 血小板生成素 粒细胞集落刺激因子 粒-巨噬细胞集落刺激因子 

分 类 号：R551.3[医药卫生—血液循环系统疾病] R973.1[医药卫生—内科学]