血栓心脉宁辅助静脉溶栓对急性脑梗塞患者神经功能的影响  

Effect of Xueshuan Xinmaining assisted intravenous thrombolysis on neurological function in patients with acute cerebral infarction

作　　者：杨颖[1] 孙威[1] 滕秀涵[1] 张鑫 李雪媛[1] YANG Ying;SUN Wei;TENG Xiuhan;ZHANG Xin;LI Xueyuan(The Third People’s Hospital of Dalian,Dalian 116033)

机构地区：[1]辽宁省大连市第三人民医院,辽宁大连116033

出　　处：《湖北中医药大学学报》2021年第6期62-64,共3页Journal of Hubei University of Chinese Medicine

基　　金：辽宁省科学技术厅项目(项目编号:20191006)。

摘　　要：目的观察血栓心脉宁辅助静脉溶栓对急性脑梗塞(ACI)患者神经功能的影响。方法将我院收治的120例ACI患者按随机数字表法分为观察组与对照组各60例。观察组给予血栓心脉宁辅助阿替普酶静脉溶栓,对照组给予阿替普酶静脉溶栓,比较两组临床疗效和治疗前后患者的生活能力、神经功能、血液流变学、血管内皮功能。结果治疗后,观察组总有效率显著高于对照组( P<0.05);两组改良版日常生活能力量表(BI)增加,美国公立卫生研究院卒中量表(NIHSS)下降,且观察组BI指数高于对照组,NIHSS低于对照组( P<0.05);两组血浆黏度、高切和低切全血黏度下降,且观察组血浆黏度、高切和低切全血黏度低于对照组;两组患者血清内皮素-1(ET-1)水平下降,一氧化氮(NO)水平增高,且观察组患者血清ET-1水平低于对照组,NO水平高于对照组。结论血栓心脉宁辅助静脉溶栓治疗ACI疗效显著,能显著患者恢复生活能力和神经功能,其原因可能与血液流变学指标改善和血管内皮损伤减轻有关。Objective To observe the effect of Xueshuan Xinmaining assisted intravenous thrombolysis on the neurological function of patients with acute cerebral infarction(ACI). Methods A total of 120 patients with ACI were randomly divided into observation group and control group,each with 60 cases. Observation group was given Xueshuan Xinmaining assisted intravenous thrombolysis with alteplase,and control group was given intravenous thrombolysis with alteplase. The clinical effects of the two groups were compared,and the living ability,neurological function,hemorheology,and vascular endothelium were compared before and after treatment. Results After treatment,the total effective rate of observation group was significantly higher than control group( P<0.05);the modified version of the Barthel Index(BI)increased in both groups,and the National Institutes of Public Health Stroke Scale(NIHSS)decreased;the BI index of observation group was higher than control group,and the NIHSS was lower than control group (P<0.05);the plasma viscosity,high-cut and low-cut whole blood viscosity of both groups decreased,and were lower in observation than control group;serum endothelin-1(ET-1)level decreased,and nitric oxide(NO)level increased in both groups;the serum ET-1 level of observation group was lower than control group,and the NO level was higher than control group. Conclusion Xueshuan Xinmaining has a significant effect in treatment of ACI with assisted intravenous thrombolysis,which can significantly restore life ability and neurological function of patients. The reason might be related to the improvement of hemorheological indexes and the reduction of vascular endothelial damage.

关 键 词：急性脑梗塞 血栓心脉宁 静脉溶栓 神经功能 

分 类 号：R259[医药卫生—中西医结合]