秦氏“头八针”结合多奈哌齐治疗阿尔茨海默病认知障碍临床观察  

Clinical Observation on Qin’s Eight Scalp Acupuncture combined with donepezil on cognitive impairment of Alzheimer’s disease

作　　者：周雪[1] 王月花 王艳 莫雪蕊 阳月 崔花顺[4] ZHOU Xue;WANG Yuehua;WANG Yan;MO Xuerui;YANG Yue;CUI Huashun(The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Community Health Service Center of Juquan New Town,Gucun Town,Baoshan District,Shanghai 201907;The Fifth Rehabilitation Hospital of Shanghai Songjiang District,Shanghai 201699;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203)

机构地区：[1]安徽医科大学第一附属医院,安徽合肥230022 [2]上海市宝山区顾村镇菊泉新城社区卫生服务中心,上海201907 [3]上海市松江区第五康复医院,上海201699 [4]上海中医药大学附属曙光医院,上海201203

出　　处：《湖北中医药大学学报》2021年第6期109-113,共5页Journal of Hubei University of Chinese Medicine

基　　金：国家自然科学基金项目(项目编号:82074535);第四批全国中医临床优秀人才研修项目(国中医药人教发[2017]24号);上海市中医药科技创新项目(项目编号:ZYKC201702001)。

摘　　要：目的观察秦氏"头八针"为主结合多奈哌齐治疗轻中度阿尔茨海默病(AD)认知障碍的临床疗效。方法将我院66例AD患者随机分为观察组与对照组各33例。观察组采用秦氏"头八针"组穴针刺联合口服多奈哌齐治疗,对照组口服多奈哌齐治疗,观察两组治疗前后的简易精神状态检查(MMSE)量表、阿尔茨海默病评定量表-认知分量表(ADAS-cog)、Barthel指数(BI)评定量表、功能活动调查表(FAQ)及中医证候积分的变化,并比较两组的整体临床有效率。结果治疗后,观察组临床有效率显著高于对照组(P<0.05);观察组MMSE量表得分、ADAS-cog得分、FAQ得分、中医证候积分均优于治疗前(P<0.05),且优于对照组(P<0.05);观察组Barthel指数评定量表评分优于治疗前(P<0.05),但与对照组无明显差异(P>0.05)。结论以头针为主针刺结合多奈哌齐干预轻中度阿尔茨海默病,能够有效地改善患者的认知障碍,明显提高临床疗效,并从整体上提高患者的生存质量。Objective To observe the therapeutic effect of Qin’s Eight Scalp Acupuncture combined with donepezil in treatment of cognitive impairment of mild and moderate Alzheimer’s disease(AD).Method Patients AD were randomly divided into observation group and control group with 33 cases each.Observation group received treatment of Qin’s Eight Scalp Acupuncture and donepezil,while control group was treated with donepezil only.The scores of MMSE,ADAS-cog,Barthel index(BI),FAQ and TCM syndrome integral were recorded respectively both at the beginning and the end of the trial.Finally the total therapeutic effect were estimated between the two groups.Result Of 66 participants enrolled in the study,64 patients finished their treatment and follow-up processes,including 31 in observation group and 33 in control group.After treatment,the scores of MMSE,ADAS-COG,FAQ and TCM syndrome integral in observation group were better than those before treatment(P<0.05),and better than those in control group(P<0.05);the scores of BI in observation group were better than those before treatment(P<0.05),but showed no significant difference from control group;the clinical effective rate of observation group was significantly higher than that of control group(P<0.05).Conclusion Qin’s Eight Scalp Acupuncture combined with donepezil can significantly improve the cognitive impairment,clinical efficacy and overall life quality of mild and moderate AD patients.

关 键 词：阿尔茨海默病 秦氏“头八针” 针刺 认知障碍 临床疗效 

分 类 号：R245.3[医药卫生—针灸推拿学]