肺部扩散加权成像影像组学特征的稳健性及再现性探讨  

The stability and repeatability of radiomics features based on lung diffusion-weighted imaging

作　　者：万齐[1] 王宇泽 李新春[1] 夏晓颖 王鹏[1] 彭玉 梁长虹[2] Wan Qi;Wang Yuze;Li Xinchun;Xia Xiaoying;Wang Peng;Peng Yu;Liang Changhong(Department of Radiology,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China;Department of Radiology,Guangdong Provincial People′s Hospital,Guangzhou 510080,China)

机构地区：[1]广州医科大学附属第一医院放射科,广州510120 [2]广东省人民医院放射科,广州510080

出　　处：《中华医学杂志》2022年第3期190-195,共6页National Medical Journal of China

基　　金：国家自然科学基金(81601457);广州市科技局项目(202102010253)。

摘　　要：目的探讨肺部扩散加权成像(DWI)影像组学特征的稳健性及再现性。方法前瞻性连续收集2019年1月4日至5月5日广州医科大学附属第一医院放射科行MRI检查的30例肺部结节/肿块患者,其中男16例,女14例,年龄27~69(57±11)岁。所有患者在自由呼吸状态下接受肺部平面回波成像(EPI)-DWI及快速自旋回波(TSE)-DWI检查,检查完成后间隔5 min各序列重复扫描一次,并重建相应的表观扩散系数(ADC)图。由两名放射科医师对各DWI及ADC序列(共8组图像)分别进行手动分割,并对每组图像提取6大类共396个影像组学特征。使用一致性相关系数(CCC)、动态范围(DR)评估两次扫描间特征的稳健性,以CCC和DR均≥0.85为稳健特征。通过组内相关系数(ICC)评估观察者内和观察者间特征的再现性,以ICC≥0.75为再现性好的特征。结果无论EPI或TSE技术,基于DWI图(TSE:n=197,EPI:n=169)提取的稳健特征数量均高于相应的ADC图(TSE:n=126,EPI:n=148)。TSE-DWI、TSE-ADC、EPI-DWI、EPI-ADC稳健特征占比分别为49.7%(197/396)、31.8%(126/396)、42.7%(169/396)、37.4%(148/396)。396个特征中有54个(13.6%)在所有序列中均表现出很好的稳健性(CCC和DR均≥0.85),且观察者内和观察者间具有很好的再现性(ICC≥0.75)。结论肺DWI影像组学特征具有一定的稳健性及再现性;不同序列及不同特征簇中具有不同比例的稳定特征,部分特征在不同扫描间、不同观察者间,甚至不同序列间都有很好的稳健性和再现性。Objective To evaluate the feasibility,robustness and reproducibility of radiomics features derived from lung diffusion-weighted imaging(DWI).Methods Thirty patients with pulmonary nodules/masses who underwent magnetic resonance imaging examination in the Department of Radiology,the First Affiliated Hospital of Guangzhou Medical University,from January 42019 to May 52019,including 16 males and 14 females,aged from 27 to 69(57±11)years,were prospectively collected.Planar echo imaging(EPI)-DWI and fast spin-echo(TSE)-DWI scans were performed under free-breathing conditions.Each scan was repeated at an interval of 5 minutes,and the corresponding apparent diffusion coefficient(ADC)maps were reconstructed.Each DWI and ADC sequence(a total of eight groups of images)were manually segmented by two radiologists,and a total of 396 radiomics features in 6 categories were extracted from each group of images.Consistency correlation coefficient(CCC)and dynamic range(DR)were used to evaluate the robustness of features between two scans,and stable features were defined as both CCC values and DR values≥0.85.Intra-observer and interobserver reproducibility were evaluated by intra-group correlation coefficient(ICC),and ICC values≥0.75 was considered to be good reproducibility.Results Regardless of EPI or TSE technique,the number of robust features extracted fromDWI(TSE:n=197,EPI:n=169)were higher than that of the corresponding ADC(TSE:n=126,EPI:n=148).The proportion of robust features of TSE-DWI、EPI-DWI、TSE-ADC、EPI-ADC was 49.7%(197/396),42.7%(169/396),31.8%(126/396)and 37.4%(148/396),respectively.Of the 396 features,54(13.6%)of them demonstrated great robustness(CCC and DR≥0.85)and interobserver and interobserver reproducibility(ICC≥0.75)across all sequences.Conclusions Radiomics features derived from lung DWI showed robustness and reproducibility.Different sequences and different feature clusters have different proportions of stable features,and some features have good robustness and reproducibility between differen

关 键 词：放射学 影像组学 磁共振 肺部 可重复性 

分 类 号：R445.2[医药卫生—影像医学与核医学] R734.2[医药卫生—诊断学]