Reinfection rates among patients previously infected by SARS-CoV-2:systematic review and meta-analysis  

作　　者：Yinjun Mao Weiwei Wang Jun Ma Shanshan Wu Feng Sun 

机构地区：[1]Department of Pharmacy,First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian 350005,China [2]National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China [3]Institute of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,China [4]Department of Gastroenterology,Beijing Friendship Hospital,Capital Medical University,National Clinical Research Center for Digestive Disease,Beijing Digestive Disease Center,Beijing Key Laboratory for Precancerous Lesion of Digestive Disease,Beijing,100050,China [5]Department of Epidemiology and Biostatistics,School of Public Health,Peking University Health Science Centre,Beijing 100191,China

出　　处：《Chinese Medical Journal》2022年第2期145-152,共8页中华医学杂志（英文版）

基　　金：This study is funded by grants from the National Natural Science Foundation of China(No.72074011);the National Key Technology R&D Program of China(No.2020YFC0840800);the National Key R&D Program of China(No.2021YFC2301601).

摘　　要：Background:Asymptomatic or symptomatic infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can be followed by reinfection.The protection conferred by prior infection among coronavirus disease 2019(COVID-19)patients is unclear.We assessed the incidence of SARS-CoV-2 reinfection and the protection effect of previous infection against reinfection.Methods:We searched PubMed,EMBASE,Cochrane,Scopus,Web of Science,and ClinicalTrials.gov for publications up until the end date of May 1,2021.The reinfection rate of recovered patients and the protection against reinfection were analyzed using meta-analysis.Results:Overall,19 studies of 1096 reinfection patients were included.The pooled reinfection rate was 0.65%(95%confidence interval[CI]0.39-0.98%).The symptomatic reinfection rate was a bit lower(0.37%[95%CI 0.11-0.78%],I^(2)=99%).The reinfection rate was much higher in high-risk populations(1.59%[95%CI 0.30-3.88%],I^(2)=90%).The protection against reinfection and symptomatic reinfection was similar(87.02%[95%CI 83.22-89.96%]and 87.17%[95%CI 83.09-90.26%],respectively).Conclusions:The rate of reinfection with SARS-CoV-2 is relatively low.The protection against SARS-CoV-2 after natural infection is comparable to that estimated for vaccine efficacy.These data may help guide public health measures and vaccination strategies in response to the COVID-19 pandemic.High-quality clinical studies are needed to establish the relevant risk factors in recovered patients.

关 键 词：COVID-19 REINFECTION SARS-COV-2 RATE 

分 类 号：R563.1[医药卫生—呼吸系统]