早产儿支气管肺发育不良并发肺动脉高压的危险因素分析  

Risk Factors for Bronchopulmonary Dysplasia Complicated with Pulmonary Hypertension in Preterm Infants

作　　者：岳伟红[1] 余加林[1] Yue Weihong;Yu Jialin(Children’s Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,National Clinical Research Center for Child Health and Disorders,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿童发育重大疾病国家国际科技合作基地,儿科学重庆市重点实验室,重庆400014

出　　处：《儿科药学杂志》2022年第2期42-46,共5页Journal of Pediatric Pharmacy

摘　　要：目的:探讨早产儿支气管肺发育不良(BPD)并发肺动脉高压(PH)的危险因素。方法:回顾性分析202例BPD患儿的临床资料,根据是否并发PH分为并发PH组(n=79)和未并发PH组(n=123),采用单因素和多因素Logistic回归分析法,总结BPD并发PH的危险因素。结果:单因素分析显示,两组在小于胎龄儿(SGA)、呼吸窘迫综合征(RDS)、有血流动力学意义的动脉导管未闭(hsPDA)、败血症、中重度BPD、有创通气≥7 d等指标比较差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,RDS和hsPDA是BPD并发PH的独立危险因素。结论:RDS和hsPDA是BPD并发PH的独立危险因素。对于BPD患儿,临床应早期识别其危险因素并及时干预,尽可能降低并发PH的风险。Objective: To probe into the risk factors for bronchopulmonary dysplasia(BPD) complicated with pulmonary hypertension(PH) in preterm infants. Methods: Clinical data of 202 children with BPD were retrospectively analyzed, all children were divided into the PH group(n=79) and the non-PH group(n=123) according to whether BPD was complicated with PH. Univariate and multivariate Logistic regression analysis was used to summarize the risk factors of BPD complicated with PH. Results: Univariate analysis showed that there were statistically significant differences between two groups in small for gestational age(SGA), respiratory distress syndrome(RDS), haemodynamieally significant patent duetus arteriosus(hsPDA), sepsis, moderate to severe BPD, invasive ventilation ≥7 d and other indicators(P<0.05). Multivariate analysis showed that RDS and hsPDA were independent risk factors for BPD complicated with PH. Conclusion: RDS and hsPDA are independent risk factors for BPD complicated with PH. For children with BPD, clinical risk factors should be identified early, timely intervention should be made to reduce the risks of BPD complicated with PH.

关 键 词：早产儿 支气管肺发育不良 肺动脉高压 危险因素 

分 类 号：R722.6[医药卫生—儿科]