Nucleobase,nucleoside,nucleotide,and oligonucleotide coordinated metal ions for sensing and biomedicine applications  

作　　者：Jiaojiao Zhou Heyou Han Juewen Liu 

机构地区：[1]State Key Laboratory of Agricultural Microbiology,College of Food Science and Technology,Huazhong Agricultural University,Wuhan 430070,China [2]Department of Chemistry,Waterloo Institute for Nanotechnology,University of Waterloo,Waterloo,ON N2L 3G1,Canada

出　　处：《Nano Research》2022年第1期71-84,共14页纳米研究（英文版）

基　　金：support from Natural Sciences and Engineering Research Council of Canada(NSERC);National Natural Science Foundation of China(No.21778020).

摘　　要：Metal ions play critical roles in chemical,biological,and environmental processes.Various biomolecules have the ability to coordinate with metal ions and form various materials.Nucleobases,nucleosides,and nucleotides,as the essential components of DNA,have emerged as a useful building block for the construction of functional nanomaterials.In recent years,DNA oligonucleotides have also been used for this purpose.We herein review the strategies for the synthesis of soft nanomaterials through the assembly of nucleotides(or DNA)and metal ions to yield various nanoparticles,fibers,and hydrogels.Such coordination methods are simple to operate and can be carried out under ambient conditions.The luminescent,catalytic,and molecular recognition properties of these coordination materials are described with representative recent examples.Their applications ranging from biosensing,enzyme encapsulation,catalysis,templated shell growth to cancer therapy are highlighted.Finally,challenges of this field and future perspectives are discussed.

关 键 词：NUCLEOTIDES DNA metal ions self-assembly nanostructures 

分 类 号：R318[医药卫生—生物医学工程]