土贝母苷甲抗肿瘤机制研究进展  

Research progress on anti-tumor mechanism of Tubeimoside-1

作　　者：孙柳 苗雪圆 彭清 刘丽娜 张庆怀[2] 张春泽[2] Sun Liu;Miao Xueyuan;Peng Qing;Liu Lina;Zhang Qinghuai;Zhang Chunze(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Anorectal Surgery,Tianjin People's Hospital,Tianjin 300121,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津市人民医院肛肠外科,天津300121

出　　处：《国际中医中药杂志》2022年第1期110-113,共4页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81872263);天津市科技支撑重点研发计划项目(19YFZCSY00420)。

摘　　要：土贝母苷甲为葫芦科植物土贝母中含量较大,水溶性、稳定性较好的三萜皂苷类活性成分,对肺癌、结直肠癌、乳腺癌、胃癌等多种肿瘤具有广泛的抑制作用。其机制主要与抑制肿瘤细胞生长、诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭转移、诱导细胞自噬、抑制肿瘤血管生成等途径相关。Tubeimoside-1(TBMS1)is a triterpene saponins active components with large content in Cucurbitaceae plant Fritillaria,which is water-soluble and stable.It has a broad inhibitory effect on lung cancer,colorectal cancer,breast cancer,gastric cancer and other tumors.The mechanism is mainly related to the inhibition of tumor cell growth,induction of tumor cell apoptosis,inhibition of tumor cell invasion and metastasis,induction of cell autophagy,and inhibition of tumor angiogenesis.

关 键 词：土贝母 土贝母皂苷甲 肿瘤 抗肿瘤药 植物(中药) 作用机制 综述 

分 类 号：R285[医药卫生—中药学]