Wnt/β-catenin信号通路在脂溢性脱发中的作用及中药干预的研究进展  

Role of Wnt/β-catenin Signaling Pathway in Seborrheic Alopecia and Its Intervention with Traditional Chinese Medicine:A Review

作　　者：徐玲玲 玄敏 李挺 魏雅平 吴仪 玄振玉 XU Ling-ling;XUAN Min;LI Ting;WEI Ya-ping;WU Yi;XUAN Zhen-yu(School of Traditional Chinese Medicine(TCM),Shanghai University of TCM,Shanghai 200120,China;The Eighth People's Hospital of Qingdao,Qingdao 266000,China;Suzhou Youseen New Drug R&D Co.Ltd,Suzhou 215028,China)

机构地区：[1]上海中医药大学中药学院,上海200120 [2]山东省青岛市第八人民医院,山东青岛266000 [3]苏州玉森新药开发有限公司,苏州215028

出　　处：《中国实验方剂学杂志》2022年第4期254-261,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家“重大新药创制”科技重大专项(2018ZX09731016)。

摘　　要：脂溢性脱发是一种多因素引起的慢性皮肤科疾病,多发病于20~30岁的青壮年男性,临床表现主要为头发油腻、瘙痒、多屑、发际线后移、头顶部毛发稀疏脱落、额颞区进行性脱发等。脂溢性脱发虽不致命,但有碍容颜,严重影响患者自尊,给患者带来极大的心理困扰。Wnt/β-连环蛋白(β-catenin)信号通路广泛存在于多细胞真核生物中,是一种基本的生长调控途径,具有调节细胞的增生、分化,维持干细胞的活性及器官稳态,影响细胞的迁移等作用。目前,国内外已有研究报道,Wnt/β-catenin信号通路与脂溢性脱发的发生发展及药物作用机制密切相关。中药具有多成分、多靶点、多途径的治疗优势,可以通过调控Wnt/β-catenin信号通路促进毛囊基板发生、毛囊干细胞增殖、分化及毛囊周期性变化等,从而改善脂溢性脱发。本文综述了Wnt/β-catenin信号通路及其中关键靶点蛋白因子与脂溢性脱发的关系,以明确Wnt/β-catenin信号通路对脂溢性脱发的重要作用。同时,对靶向调控Wnt/β-catenin信号通路从而治疗脂溢性脱发疾病的中药进行系统性总结,以期为脂溢性脱发疾病的治疗以及进一步的药物开发提供理论依据。Seborrheic alopecia is a chronic dermatological disease caused by multiple factors.It occurs frequently in young and middle-aged men aged 20-30 years.The main clinical manifestations are greasy hair,itching,excessive dandruff,receding hairline,sparse hair on the top of the head,and progressive hair loss in the frontotemporal area.Seborrheic alopecia is not fatal,but it affects the appearance of patients,seriously harming their self-esteem and bringing great psychological distress to them.The Wnt/β-catenin signaling pathway widely exists in multicellular eukaryotes and is a basic growth regulatory pathway which regulates cell proliferation and differentiation,maintains stem cells activity and organ homeostasis,and affects cell migration.At present,it has been reported in China and abroad that Wnt/β-catenin signaling pathway is closely related to the occurrence and development of seborrheic alopecia and the action mechanism of drugs.Traditional Chinese medicine(TCM)has multi-component,multi-target,and multi-pathway advantages,and it can promote the formation of hair follicle laminae,the proliferation and differentiation of hair follicle stem cells,and the periodic changes in hair follicles by regulating the Wnt/β-catenin signaling pathway,thereby alleviating seborrheic alopecia.This article reviewed the relationship of Wnt/β-catenin signaling pathway and its key target protein factors with seborrheic alopecia to clarify the important role of Wnt/β-catenin signaling pathway in seborrheic alopecia.At the same time,the TCM that targeted the Wnt/β-catenin signaling pathway to relieve seborrheic alopecia were summarized,so as to provide reference for the treatment of seborrheic alopecia and further development of new drugs.

关 键 词：Wnt/β-连环蛋白(β-catenin)信号通路 脂溢性脱发 中药 作用机制 

分 类 号：R2-0[医药卫生—中医学] R22