吸烟与冠状动脉微血管功能障碍关系的研究新进展  

Progress in research on smoking and coronary microvascular dysfunction

作　　者：安换换 李婉琳(综述) 迟锦玉(审校)[1] An Huanhuan;Li Wanlin;Chi Jinyu(Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Heilongjiang Province,Harbin 150001, China)

机构地区：[1]哈尔滨医科大学附属第一医院心内科,哈尔滨150001

出　　处：《疑难病杂志》2022年第2期212-215,220,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金资助项目(81800352)。

摘　　要：冠状动脉微血管功能障碍(CMD)是由于冠状动脉微血管功能异常导致心肌供血和耗氧量不匹配,可伴有或不伴有阻塞性冠状动脉疾病等多种心血管疾病,与不良临床事件密切相关。目前有研究表明,吸烟可促进CMD发生发展,但其发生机制尚未明确;同时尚有流行病学研究表明,急性冠状动脉综合征吸烟者的长期预后优于不吸烟者,这种现象被视为吸烟悖论。因此,文章主要对吸烟造成CMD的机制进行综述。Coronary microvascular dysfunction(CMD)is a mismatch between myocardial blood supply and oxygen consumption due to abnormal coronary microvascular function,with or without obstructive coronary artery disease and other cardiovascular diseases,and is closely related to adverse clinical events.At present,studies have shown that smoking can promote the development of CMD,but its mechanism is not yet clear.At the same time,there are epidemiological studies showing that the long-term prognosis of smokers with acute coronary syndrome is better than that of non-smokers,which is regarded as the smoking paradox.Therefore,this article mainly reviews the mechanism of smoking-induced CMD.

关 键 词：冠状动脉微血管功能障碍 吸烟 作用机制 研究进展 

分 类 号：R541.4[医药卫生—心血管疾病]