Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population  

作　　者：WANG Jia Lu CAO Qiu Yu XIN Zhuo Jun LIU Shan Shan XU Min WANG Tian Ge LU Jie Li CHEN Yu Hong WANG Shuang Yuan ZHAO Zhi Yun XU Yu NING Guang WANG Wei Qing BI Yu Fang LI Mian 

机构地区：[1]Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [2]Shanghai National Clinical Research Center for Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China,Shanghai Key Laboratory for Endocrine Tumor,State Key Laboratory of Medical Genomics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《Biomedical and Environmental Sciences》2022年第1期4-12,共9页生物医学与环境科学（英文版）

基　　金：supported by the grants from the National Key R&D Program of China[2017YFC1310700,2016YFC1305600,2016YFC0901200,2016YFC1305202,2016YFC1304904,2018YFC1311800,2018YFC1311705];the National Natural Science Foundation of China[81870560,81561128019,81621061,81700764,81941017,81770842];the Chinese Academy of Medical Sciences[2018PT32017,2019PT330006];the Shanghai Municipal Government[18411951800];the Shanghai Shenkang Hospital Development Center[SHDC12019101];Shanghai Municipal Commission of Health and Family Planning[20174Y0014];National Major Scientific and Technological Special Project for“Significant New Drugs Development”[2017ZX09304007];Shanghai Rising-Star Program[21QA1408100];the Scientific and Technological Committee of Shanghai[19411964200];Innovative research team of high-level local universities in Shanghai;the Shanghai Jiaotong University School of Medicine[DLY201801,20161301,20161307];the Ruijin Hospital[2018CR002]。

摘　　要：Objective The association between neutrophil-to-lymphocyte ratio(NLR)with subclinical macrovascular and microvascular diseases has been less investigated.We sought to examine the association between NLR and new-onset subclinical macrovascular and microvascular abnormalities in the Chinese population.Methods From a community cohort,we included 6,430 adults aged≥40 years without subclinical macrovascular and microvascular diseases at baseline.We measured subclinical macrovascular and microvascular abnormalities separately using the ankle-brachial index(ABI),brachial-ankle pulse wave velocity(baPWV),and albuminuria.Results During a mean follow-up of 4.3 years,110 participants developed incident abnormal ABI,746 participants developed incident elevated baPWV,and 503 participants developed incident albuminuria.Poisson regression analysis indicated that NLR was significantly associated with an increased risk of newonset abnormal ABI,elevated baPWV,and albuminuria.Compared to overweight/obese participants,we found a much stronger association between NLR and subclinical vascular abnormalities in participants with normal weight.Furthermore,we found an interaction between the NLR and body mass index(BMI)on the risk of new-onset abnormal ABI(P for interaction:0.01).Conclusion NLR was associated with subclinical macrovascular and microvascular diseases in the Chinese population.Furthermore,in participants with normal weight,the association between NLR and subclinical vascular abnormalities was much stronger.

关 键 词：Neutrophil-to-lymphocyte ratio Subclinical macrovascular and microvascular diseases Body mass index Prospective cohort study 

分 类 号：R543[医药卫生—心血管疾病]