Optimal control analysis of hepatocytic-erythrocytic dynamics of Plasmodium falciparum malaria  

作　　者：Titus Okello Orwa Rachel Waema Mbogo Livingstone Serwadda Luboobi 

机构地区：[1]Institute of Mathematical Sciences,Strathmore University,P.O Box 59857-00200,Nairobi,Kenya

出　　处：《Infectious Disease Modelling》2022年第1期82-108,共27页传染病建模（英文）

摘　　要：This paper presents an in-host malaria model subject to anti-malarial drug treatment and malaria vaccine antigens combinations.Pontryagin's Maximum Principle is applied to establish optimal control strategies against infected erythrocytes,infected hepatocytes and malaria parasites.Results from numerical simulation reveal that a combination of preerythrocytic vaccine antigen,blood schizontocide and gametocytocide drugs would offer the best strategy to eradicate clinical P.falciparum malaria.Sensitivity analysis,further reveal that the efficacy of blood schizontocides and blood stage vaccines are crucial in the control of clinical malaria infection.Futhermore,we found that an effective blood schizontocide should be used alongside efficacious blood stage vaccine for rapid eradication of infective malaria parasites.The authors hope that the results of this study will help accelerate malaria elimination efforts by combining malaria vaccines and anti-malarial drugs against the deadly P.falciparum malaria.

关 键 词：Optimal control Blood schizontocide Gametocytocide P.falciparum malaria Malaria vaccines Pontryagin's Maximum Principle 

分 类 号：R531.3[医药卫生—内科学]