自发性早产与妊娠中期羊水炎症细胞因子水平及解脲脲原体感染关系研究  

Study on the Relationship between Spontaneous Preterm Labor and Amniotic Fluid Inflammatory Cytokines and Ureaplasma Urealyticum Infection in the Second Trimester of Pregnancy

作　　者：韩会杰 孙君侠[1] 毕姝洁 雷凤英 王冬梅 张英欣[1] 张丽[1] 云白惠 Han Huijie;Sun Junxia;Bi Shujie;Lei Fengying;Wang Dongmei;Zhang Yingxin;Zhang Liyun;Bai Hui(Department of Obstetrics and Gynecology,Tangshan Union Hospital,Tangshan 063000,Hebei,China)

机构地区：[1]唐山市协和医院妇产科,河北省唐山市063000

出　　处：《中国病案》2022年第1期97-100,共4页Chinese Medical Record

基　　金：河北省卫计委课题(20191630)。

摘　　要：目的探讨妊娠中期羊水中炎性细胞因子水平及解脲脲原体感染与自发性早产的关系。方法选取2017年1月1日-2019年12月31日在某院自发性早产产妇87例为观察组,同时选取足月分娩正常产妇174例为对照组,比较2组妊娠中期羊水单核细胞趋化蛋白-1(MCP-1)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)及白细胞介素16(IL-16)水平差异,观察2组羊水解脲脲原体感染情况,比较观察组解脲脲原体感染对MCP-1、CRP、TNF-α、IL-8、IL-16水平的影响。结果观察组羊水中MCP-1为(1426.21±216.41)pg/ml,高于对照组的(1022.18±177.60)pg/ml;观察组羊水中CRP、TNF-α、IL-16及IL-8高于对照组;观察组羊水解脲脲原体感染率为8.05%,高于对照组的1.25%;观察组解脲脲原体感染产妇羊水MCP-1水平为(2980.40±379.26)pg/ml,高于未感染产妇的(1250.02±213.74)pg/ml;观察组解脲脲原体感染产妇羊水CRP、TNF-α、IL-8及IL-16水平高于未感染产妇,差异均有统计学意义(P<0.05)。结论自发性早产患者羊水解脲脲原体感染率高,炎症细胞因子水平增高,其可能在自发性早产的发生过程中具有重要的作用。Objective To investigate the relationship between spontaneous preterm delivery and inflammatory cytokines in amniotic fluid during the second trimester of pregnancy and ureaplasma urealyticum infection.Methods From January 1 st,2017 to December 31 st,2019,87 cases of spontaneous preterm deliveries in a hospital(observation group,n=87) and 174 cases of normal full-term deliveries(control group,n=174) were selected.The levels of monocyte chemotaxis protein-1(McP-1),C-reactive protein(CRP),tumor necrosis factor(TNF-),interleukin 8(IL-8)and interleukin 16(IL-16) in amniotic fluid were compared between the two groups in the second trimester of pregnancy,and the infection of ureaplasma urealyticum hydrolysate was observed between the two groups.The effects of ureaplasma urealyticum infection on THE levels of McP-1,CRP,TNF-,IL-8 and IL-16 in the observation group were compared.Results The level of MCP-1 in amniotic fluid in observation group was(1426.21±216.41) pg/mL,which was higher than that in control group(1022.18±177.60) pg/mL.The levels of CRP,TNF-,IL-16 and IL-8 in amniotic fluid in observation group were higher than those in control group.The infection rate of the observation group was 8.05%,which was higher than that of the control group(1.25%).The level of McP-1 in amniotic fluid of pregnant women with urealyticum urealyticum infection was(2980.40±379.26) pg/mL in the observation group,which was higher than that of uninfected women(1250.02±213.74) pg/mL.The levels of CRP,TNF-,IL-8 and IL-16 in amniotic fluid of pregnant women with urealyticum urealyticum infection in observation group were higher than those in non-infected women,the differences were statistically significant(P<0.05).Conclusions The infection rate of ureaplasma hydrolyzate was high and the level of inflammatory cytokines increased in spontaneous preterm labor,which might play an important role in spontaneous preterm labor.

关 键 词：自发性早产 羊水 单核细胞趋化蛋白-1 C反应蛋白 肿瘤坏死因子α 解脲脲原体 

分 类 号：R714.21[医药卫生—妇产科学]