曼月乐治疗子宫腺肌病的临床效果  

Clinical effect of Mirena in treatment of adenomyosis

作　　者：任丽芸 何少红 陈华[2] REN Li-Yun;HE Shao-Hong;CHEN Hua(Department of Gynecology,Yinchuan Second People’s Hospital,Ningxia 750011,China)

机构地区：[1]银川市第二人民医院妇科,宁夏银川750011 [2]宁夏医科大学总医院妇科,宁夏银川750004

出　　处：《中国妇幼保健》2022年第2期278-281,共4页Maternal and Child Health Care of China

基　　金：宁夏自然科学基金项目(NZ17146);宁夏医科大学科学研究基金资助项目(XY2017120)。

摘　　要：目的探讨曼月乐治疗子宫腺肌病的临床效果。方法选取2017年6月—2019年6月收治的90例子宫腺肌病患者,按照随机数字表分为对照组和研究组,每组45例。对照组应用常规药物治疗,研究组应用曼月乐治疗。比较两组治疗6个月后的临床疗效,治疗前后血红蛋白、血清糖类抗原125(CA125)及性激素水平,痛经程度,月经量,子宫内膜厚度,子宫体积。结果治疗后,研究组血红蛋白水平为(118.45±7.44)g/L,高于对照组的(110.95±8.95)g/L,研究组血清CA125水平为(26.63±4.65)mg/L,低于对照组的(36.07±5.32)mg/L,差异均有统计学意义(t=20.115,21.956,均P<0.05)。治疗后,研究组痛经程度评分、月经量分别为(1.63±0.35)分和(47.18±9.46)ml,均低于对照组[(4.55±1.45)分和(68.34±15.23)ml],差异均有统计学意义(t=19.574,18.996,均P<0.05)。治疗后,研究组子宫内膜厚度、子宫体积分别为(5.47±1.24)mm和(219.37±7.63)cm^(3),均低于对照组[(7.02±1.86)mm和(235.96±8.14)cm^(3)],差异均有统计学意义(t=20.067,21.163,均P<0.05)。治疗前后,两组血清雌二醇(E_(2))、黄体生成素(LH)及卵泡刺激素(FSH)水平比较差异均无统计学意义(P>0.05)。研究组治疗有效率为95.56%,高于对照组的80.00%,差异有统计学意义(χ^(2)=5.075,P<0.05)。结论曼月乐治疗子宫腺肌病的效果较好,能够有效改善患者子宫内膜厚度和子宫体积,降低痛经程度和月经量,同时不会引起性激素水平改变,安全性较高。Objective To explore the effect of Mirena in treatment of adenomyosis.Methods From June 2017 to June 2019,90 patients with adenomyosis were selected and divided into control group and study group according to random number table,45 patients in each group.The patients in control group were treated with routine drugs,and the patients in study group were treated with Mirena.The clinical effects after six months,the levels of hemoglobin,serum CA125,and sex hormones,the degrees of dysmenorrhea,menstrual blood volumes,endometrial thicknesses,and uterine volumes before and after treatment in the two groups were compared.Results After treatment,the level of hemoglobin in study group was(118.45±7.44) g/L,which was statistically significantly higher than that in control group [(110.95±8.95) g/L],the level of serum CA125 in study group was(26.63±4.65) mg/L,which was statistically significantly lower than that in control group [(36.07±5.32) mg/L](t=20.115,21.956,P<0.05).After treatment,dysmenorrheal score and menstrual blood volume in study group were(1.63±0.35) and(47.18±9.46) ml,respectively,which were statistically significantly lower than those in control group [(4.55±1.45) and(68.34±15.23) ml](t=19.574,18.996,P<0.05).After treatment,endometrial thickness and uterine volume in study group were(5.47±1.24) mm and(219.37±7.63) cm^(3),respectively,which were statistically significantly lower than those in control group [(7.02±1.86) mm and(235.96±8.14) cm^(3)](t=20.067,21.163,P<0.05).There was no statistically significant difference in the levels of estradiol(E_(2)),luteinizing hormone(LH),and follicle-stimulating hormone(FSH) between before and after treatment(P>0.05).The effective rate of treatment in study group was 95.56%,which was statistically significantly higher than that in control group(80.00%)(χ^(2)=5.075,P<0.05).Conclusion The effect of Mirena in treatment of adenomyosis is good,Mirena can effectively improve endometrial thickness and uterine volume,reduce the degree of dysmenorrhea and menstrual volu

关 键 词：曼月乐 子宫腺肌病 效果 

分 类 号：R711.74[医药卫生—妇产科学]