SNAPC3基因rs12093多态性与缺血性中风风证显著关联  

SNAPC3 gene rs12093 polymorphism is significantly associated with ischemic stroke wind syndrome

作　　者：古联[1] 黄先利 严雁[2] 杨怡冰 唐略钧 苏莉[3] GU Lian;HUANG Xian-li;YAN Yan;YANG Yi-bing;TANG Lue-jun;SU Li(The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China;Guangxi University of Chinese Medicine,Nanning 530001,China;School of Public Health,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023 [2]广西中医药大学,广西南宁530001 [3]广西医科大学公共卫生学院,广西南宁530021

出　　处：《海南医学院学报》2022年第2期111-117,共7页Journal of Hainan Medical University

基　　金：国家自然科学基金项目(81573756);国家自然科学基金项目(81473670)。

摘　　要：目的:探索小核RNA激活复合体多肽3(SNAPC3)rs12093多态性与缺血性中风及其中医证候的关联。方法:纳入研究缺血性中风病例774例,对照793例。使用Massarray技术进行基因分型检测,应用PLINK软件进行遗传关联分析统计。结果:(1)SNAPC3基因rs12093多态性与缺血性中风风证发生风险显著关联[显性模型:OR=0.76,95%CI(0.58~0.99),P=0.047]。(2)在校正年龄、性别后,SNAPC3基因rs12093多态性与缺血性中风风证评分相关联(显性模型:P_(adj)=0.037;隐性模型:P_(adj)=0.009)。(3)在校正性别、年龄后,SNAPC3基因rs12093多态性与缺血性中风风证患者的血小板(加性模型:P_(adj)=0.024;显性模型:P_(adj)=0.039)、凝血酶时间(显性模型:P_(adj)=0.042)水平显著相关。结论:SNAPC3基因rs12093多态性可能与缺血性中风风证发生发展相关。Objective:To investigate whether the small nuclear RNA activating complex polypeptide 3(SNAPC3)gene rs12093 polymorphism is associated with ischemic stroke(IS)and Traditional Chinese Medicine(TCM)syndromes of IS.Meth⁃ods:This study enrolled 774 patients with ischemic stroke(IS)and 793 normal controls.Massarray technology was used for geno-typing.And genetic association analysis was estimated by PLINK program.Results:(1)SNAPC3 gene rs12093 polymorphism was significantly associated with the risk of ischemic stroke wind syndrome of IS[OR=0.76,95%CI(0.58‒0.99),P=0.047 in dominant model].(2)After adjusting age and gender,SNAPC3 gene rs12093 polymorphism and the score of ischemic stroke wind syndrome(P_(adj)=0.037 in additive model;P_(adj)=0.009 in recessive model),the correlation was statistically significant.(3)After adjusting age and gender,platelet(PLT)(P_(adj)=0.024 in addiction model;P_(adj)=0.039 in dominant model)and thrombin time(TT)(P_(adj)=0.042 in dominant model)were significantly associated with rs12093 polymorphism in patients with ischemic stroke wind syndrome.Conclusion:SNAPC3 gene rs12093 polymorphism may affect the occurrence of ischemic stroke wind syndrome.

关 键 词：缺血性中风 SNAPC3基因 基因多态性 中医证候 风证 

分 类 号：R255.2[医药卫生—中医内科学]