不同频率ASSR、ABR和40 Hz AERP反应阈值的比较及其法医学应用  

Comparison of ASSR,ABR and 40 Hz AERP Response Thresholds at Different Frequencies and Their Forensic Applications

作　　者：张馨元 罗方亮 程龙龙 熊妍荷 刘技辉 ZHANG Xin-yuan;LUO Fang-liang;CHENG Long-long;XIONG Yan-he;LIU Ji-hui(Department of Forensic Clinical Medicine,School of Forensic Medicine,China Medical University,Shenyang 110122,China;Liaoning University Expert Evidence Center,Academy of Forensic Science Liaoning Uni-versity,Shenyang 110036,China;Affiliated Zhongshan Hospital of Dalian University,Dalian 116001,Liaoning Province,China;Shanghai Love Nursing Station,Shanghai 200030,China)

机构地区：[1]中国医科大学法医学院法医临床学教研室,辽宁沈阳110122 [2]辽宁大学司法鉴定研究院辽宁大学司法鉴定中心,辽宁沈阳110036 [3]大连大学附属中山医院,辽宁大连116001 [4]上海挚爱护理站,上海200030

出　　处：《法医学杂志》2021年第6期813-816,824,共5页Journal of Forensic Medicine

基　　金：辽宁省教育厅科学技术研究资助项目(2310015025);国家重点研发计划子项目(2016YFC0800701-4-2)。

摘　　要：目的探讨听性稳态反应(auditory steady-state response,ASSR)与听性脑干反应(auditory brain⁃stem response,ABR)、40 Hz听觉相关电位(40 Hz auditory event related potential,40 Hz AERP)的频率特性和反应阈值之间的关系及法医学应用价值。方法选择听力正常的志愿者30名(60耳),在标准隔声屏蔽室内,进行纯音测听(pure tone audiometry,PTA)阈值和ASSR、ABR、40 Hz AERP反应阈值测试,并采用SPSS 22.0软件对结果进行统计分析。结果0.5 kHz和1.0 kHz频率,40 Hz AERP反应阈值与PTA阈值具有较好的相关性,并且优于ASSR和ABR反应阈值。2.0kHz和4.0kHz频率,ASSR和ABR反应阈值与PTA阈值具有较好的相关性,并且优于40 Hz AERP反应阈值。结论判断0.5 kHz和1.0 kHz频率的听力,建议采用40 Hz AERP和ASSR综合判断受试者的PTA阈值;判断2.0 kHz和4.0 kHz频率的听力,建议采用ABR和ASSR综合判断受试者的PTA阈值。通过ASSR、ABR、40 Hz AERP的组合可提高听觉功能评价的准确性。Objective To explore the relationship between the frequency characteristics and response threshold of auditory steady-state response(ASSR),auditory brainstem response(ABR)and 40 Hz auditory event related potential(40 Hz AERP),and their application values in forensic medicine.Methods Thirty volunteers with normal hearing(60 ears)were selected to perform pure tone audiometry(PTA)threshold and ASSR,ABR and 40 Hz AERP response threshold tests in the standard sound insulation shielding room,and the results were statistically analyzed by SPSS 22.0 software.Results At 0.5 kHz and 1.0 kHz frequencies,the correlation between 40 Hz AERP response threshold and PTA threshold was good,which was better than that of ASSR and ABR response threshold.At 2.0 kHz and 4.0 kHz frequencies,the correlation between ASSR and ABR response thresholds and PTA threshold was good,which was better than that of 40 Hz AERP response threshold.Conclusion To evaluate the hearing at 0.5 kHz and 1.0 kHz frequencies,it is recommended to use 40 Hz AERP and ASSR to comprehensively assess the PTA threshold of the subjects.To evaluate the hearing at 2.0 kHz and 4.0 kHz frequencies,ABR and ASSR are recommended to assess the PTA threshold of subjects comprehensively.The combination of ASSR,ABR and 40 Hz AERP can improve the accuracy of hearing function evaluation.

关 键 词：法医学 纯音测听法 阈值 听性稳态反应 听性脑干反应 40 Hz听觉相关电位 

分 类 号：D919[医药卫生—法医学]