妊娠中期孕妇血清AFP、β-HCG、uE3、Inhibin-A联合检测预测不良妊娠结局价值  

Value of the combined detections of serum alpha-fetoprotein,human chorionic gonadotropin,free estriol,and inhibin-A of pregnant women during the second trimester of pregnancy for predicting their adverse pregnancy outcomes

作　　者：罗静枝[1] 缪铃 朱春兰 鲁卫红[1] 徐小琴 LUO Jingzhi;MIAO Ling;ZHUO Chunlan;LU Weihong;XU Xiaoqin(The 904th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Wuxi, Jiangsu Province, 214000)

机构地区：[1]中国人民解放军联勤保障部队第904医院,无锡214000

出　　处：《中国计划生育学杂志》2021年第12期2671-2674,共4页Chinese Journal of Family Planning

摘　　要：目的:探究孕中期血清甲胎蛋白(AFP)、人绒毛膜促性腺激素(hCG)、游离雌三醇(uE3)和抑制素-A(Inhibin-A)联合检测预测母婴不良妊娠结局价值。方法:回顾性分析2017年1月-2019年12月于本院产前检查的600例初产妇临床资料,均于孕中期检测血清AFP、β-HCG、uE3和Inhibin-A水平,评估预测不良妊娠结局效能。结果:600例中,发生不良孕产结局34例(5.7%),不良围产儿21例(3.5%)。发生不良妊娠结局孕妇血清AFP、β-HCG、Inhibin-A水平升高,uE3下降(P<0.05)。血清AFP、β-HCG、uE3、Inhibin-A联合预测不良孕产结局的曲线下面积为0.902,预测不良围生儿的曲线下面积为0.854,预测结果与分娩后结果无差异(P>0.05)。结论:单胎初产妇孕中期血清AFP、β-HCG、uE3、Inhibin-A联合检测对不良妊娠结局有较好预测作用。Objective:To explore the combined detections of serum alpha-fetoprotein(AFP),human chorionic gonadotropin(hCG),free estriol(uE3)and inhibin-A of pregnant women during the second trimester of pregnancy for predicting their adverse pregnancy outcomes.Methods:The clinical data of 600 primiparae from January 2017 to December 2019 were analyzed retrospectively.The levels of serum AFP,β-hCG,uE3,and inhibin-A of these primiparae during the second trimester of pregnancy were detected,and which efficiency for predicting the adverse pregnancy outcomes of these primiparae was evaluated.Results:Among 600 pregnant women,there were 34(5.7%)cases with adverse pregnancy,and 21(3.5%)cases with adverse perinatal infant outcomes.The serum levels of AFP,β-HCG,and Inhibin-A of the women with adverse pregnancy outcomes had increased significantly,and their uE3 level had decreased significantly(P<0.05).The area under the curve of the combined serum AFP,β-HCG,uE3,and Inhibin-A levels for predicting the adverse maternal outcomes or the adverse perinatal infant outcomes was 0.902 or 0.854,which had no statistical significant different from that of the postpartum results(P>0.05).Conclusion:The combined serum AFP,β-HCG,uE3,and Inhibin-A of the singleton primiparas during the second trimester of pregnancy for predicting their adverse pregnancy outcomes has better predictive effect.

关 键 词：孕中期 不良妊娠结局 甲胎蛋白 Β-人绒毛膜促性腺激素 游离雌三醇 抑制素-A 预测 

分 类 号：R714.2[医药卫生—妇产科学]