孕早期白细胞介素-17及妊娠相关激素水平与不良妊娠  

Relationship between the levels of serum pregnancy-related hormones of the women during the first trimester of pregnancy and their pregnancy outcomes

作　　者：龚智勇[1] 胥银宇[1] GONG Zhiyong;XU Yinyu(Hangzhou Traditional Chinese Medicine Hospital, Zhejiang Province, 310053)

机构地区：[1]浙江省杭州市中医院,310053

出　　处：《中国计划生育学杂志》2021年第12期2675-2678,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨孕早期血清白细胞介素-17(IL-17)、β绒毛膜促性腺激素(β-HCG)、雌二醇(E_(2))、孕酮(P)水平与不良妊娠发生。方法:收集2019年8月-2021年2月本院就诊的早孕妇女590例临床资料,根据妊娠结局分为正常结局组(n=369)和不良结局组(n=221)。化学发光法检测血清IL-17、E_(2)、P和β-HCG水平。结果:590例中血清IL-17、E_(2)、P及β-HCG水平单项或多项异常380例(66.4%),其中单项IL-17异常占13.2%,E_(2)异常占12.5%,P异常占13.4%,β-HCG异常占12.2%,≥2项异常占13.1%;IL-17、β-HCG异常升高,E_(2)、P异常降低孕妇发生不良妊娠几率增加(P<0.05)。结论:早孕妇女血清IL-17、E_(2)、P和β-HCG水平异常者,不良妊娠几率增加,提示临床加以关注。Objective:To investigate the relationship between the levels of serum interleukin-17(IL-17),β-HCG,estradiol(E_(2))and progesterone(P)of the pregnant women during the first trimester of pregnancy and their pregnancy outcomes.Methods:The clinical data of 590 pregnant women during the first trimester of pregnancy from August 2019 to February 2021 were collected and were divided into group A(369 women with normal pregnancy outcomes)and group B(221 women with adverse pregnancy outcomes)according to their pregnancy outcomes.Chemiluminescence method was used to detect the levels of serum IL-17,E_(2),P andβ-HCG of the women in the two groups.Results:There were 380(66.4%)women with one or multiple of the levels of IL-17,E_(2),P,andβ-HCG,which included 13.2%women with abnormal IL-17 level only,12.5%women with abnormal E_(2) level only,13.4%women with abnormal P level only,and 12.2%women with abnormalβ-HCG level only.There were 13.1%women with≥2 abnormality of the levels of IL-17,E_(2),P,andβ-HCG.The incidence of the adverse pregnancy outcomes of the pregnant women with the abnormal increase of the IL-17 andβ-HCG levels,and the abnormal decrease of E_(2) and P levels had increased significantly(P<0.05).Conclusion:The probability of adverse pregnancy outcomes of the pregnant women with the abnormal levels of serum IL-17,E_(2),P,andβ-HCG during the first trimester of pregnancy increases,which should be paid attention in clinic.

关 键 词：早期妊娠 白细胞介素-17 雌二醇 孕酮 Β-人绒毛膜促性腺激素 不良妊娠 

分 类 号：R714.2[医药卫生—妇产科学]