血清HMGB1、sCD40L、PIGF、sFlt-1预测子痫前期价值  

The value of serum high mobility group protein,soluble CD40L,placental growth factor,and soluble vascular growth factor receptor-1 levels of the pregnant women for predicting their preeclampsia

作　　者：胡文峰 黄秀敏[1] 梁辉声 HU Wenfeng;HUANG Xiumin;LIANG Huisheng(Zhongshan Hospital Affiliate to Xiamen University, Xiamen, Fujian Province, 361004;Zhongshan Hospital of Fudan University (Xiamen Branch))

机构地区：[1]厦门大学附属中山医院,361004 [2]复旦大学附属中山医院厦门医院

出　　处：《中国计划生育学杂志》2021年第12期2683-2687,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨血清高迁移率族蛋白(HMGB1)、可溶性CD40L(sCD40L)、胎盘生长因子(PIGF)、可溶性血管生长因子受体-1(sFlt-1)预测子痫前期(PE)价值。方法:选择2019年1月-2020年12月本院产科收治的PE患者92例(PE组),分为轻度PE组(50例)和重度PE组(42例),同期产前检查正常孕妇50例为对照组,采用酶联免疫法检测各组血清HMGB1、sCD40L、PIGF、sFlt-1,采用受试者特异性曲线(ROC)分析血清各指标诊断及预测PE价值。结果:与对照组相比,PE组24 h尿蛋白、收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、血清HMGB1、sCD40L、sFlt-1水平均较高,血清PIGF水平较低,且重度PE组各指标变化幅度高于轻度PE组(均P<0.05)。经Pearson相关因素分析,PE组SBP、DBP、MAP、24 h尿蛋白与血清HMGB1、sCD40L、sFlt-1呈正相关,与PIGF呈负相关(均P<0.05)。经ROC曲线分析,血清HMGB1、sCD40L、PIGF、sFlt-1联合诊断PE可获得最佳曲线下面积(0.810),敏感度、特异度分别为81.0%、82.1%。结论:血清HMGB1、sCD40L、PIGF、sFlt-1与PE发生及其血压升高有密切关系,联合检测可预测PE患者病情发生及转归情况,为PE临床诊断提供参考依据。Objective:To investigate the values of the serum high mobility group protein(HMGB1),soluble CD40L(sCD40L),placental growth factor(PIGF),and soluble vascular growth factor receptor-1(sFlt-1)levels of the pregnant women for predicting their preeclampsia(PE).Methods:92 pregnant women with PE were selected in study group and were divided into group A(50 women with mild PE)and group B(42 women with severe PE)according to the severity of PE from January 2019 to December 2020.50 normal pregnant women were selected in control group during the same period.The levels of the serum HMGB1,sCD40L,PIGF,and sFlt-1 of the women in the three groups were measured by enzyme-linked immunoassay(ELISA).Receiver operating characteristic curve(ROC)was used to analyze the value of the levels of serum HMGB1,sCD40L,PIGF,and sFlt-1 for diagnosing and predicting PE.Results:The values of 24 h urinary protein,systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP),and the levels of serum HMGB1,sCD40L,and SFLT-1 of the women in the study group were significantly higher than those of the women in the control group,but the serum PIGF level of the women in the study group was significantly lower.The variation range of the values of 24 h urinary protein,SBP,DBP,and MAP,and the levels of serum HMGB1,sCD40L,and SFLT-1 of the women in group B was significantly higher than those of the women in group A(all P<0.05).ROC curve analysis had showed than the best value of ROC,the sensitivity,and the specificity of the combined the serum HMGB1,sCD40L,PIGF,and sFlt-1 levels for diagnosing PE were 0.810,81.0%,and 82.1%,respectively.Conclusion:The levels of serum HMGB1,sCD40L,PIGF,sFlt-1 of the pregnant women are closely related to their occurrence of PE and their increased blood pressure.The combined detections of the serum HMGB1,sCD40L,PIGF,and sFlt-1 levels can predicate the occurrence and outcomes of the pregnant women with PE,which can provide reference basis for clinical diagnosis of PE.

关 键 词：子痫前期 血清高迁移率族蛋白 可溶性CD40L 胎盘生长因子 可溶性血管生长因子受体-1 相关性 预测值 

分 类 号：R714.244[医药卫生—妇产科学]