乙烯-醋酸乙烯酯共聚物(EVA)药物递送系统在生殖健康领域的研究进展  

Research progress of the drug delivery system of ethylene-vinyl acetate copolymer in reproductive health

作　　者：董健 马彬 杨紫霞 宁美英 DONG Jian;MA Bin;YANG Zixia;NING Meiying(National Research Institute for Family Planning, Beijing, 100081;Graduate School of Peking Union Medical College)

机构地区：[1]国家卫生健康委科学技术研究所,北京100081 [2]北京协和医学院研究生院

出　　处：《中国计划生育学杂志》2021年第12期2711-2716,共6页Chinese Journal of Family Planning

基　　金：国家卫生健康委科学技术研究所中央级公益性科研院所基本科研业务费专项资金资助(2021GJZ07)。

摘　　要：乙烯-醋酸乙烯酯共聚物(EVA)是乙烯和醋酸乙烯酯(VA)单体的透明热塑性共聚物,具有良好的柔韧性、生物相容性,能够进行长期且可控的药物释放,这些特征使其成为很好的药物递送载体。EVA药物递送载体以EVA阴道环、埋植剂和透皮给药制剂等剂型应用于生殖健康领域。本文在简要介绍EVA材料相关性质的基础上,按剂型分类,对EVA药物递送系统在生殖健康领域的相关研究进展进行归纳总结,分析EVA药物递送载体在生殖健康领域的优势及不足,以期更好地拓展EVA在生殖健康领域的应用。Ethylene-vinyl acetate copolymer(EVA)is a transparent thermoplastic copolymer of ethylene and vinyl acetate(VA)monomer.EVA is an excellent drug delivery vehicle due to its good flexibility,biocompatibility,and the ability to deliver drugs during long period and in a controlled manner.EVA drug delivery vehicles have been used in reproductive health filed in the form of EVA intravaginal ring,EVA implants,and EVA transdermal drug delivery system.This article reviews the research progress of EVA drug delivery system in reproductive health filed according to the classification of dosage forms based on a brief introduction of EVA materials.Finally the advantages and disadvantages of EVA drug delivery system were summarized in order to the widely application of EVA in reproductive health filed.

关 键 词：乙烯-醋酸乙烯酯共聚物 药物递送系统 阴道环 埋植剂 透皮给药系统 

分 类 号：R943[医药卫生—药剂学]