轻型地中海贫血孕妇孕晚期血液特点及妊娠结局  

Blood characteristics of women with mild thalassemia during the third trimester of pregnancy and their influence on pregnancy outcomes

作　　者：王金梅 郑琳 WANG Jinmei;ZHENG Lin(Wuxi Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, 214000)

机构地区：[1]南京医科大学附属无锡妇幼保健院,214000

出　　处：《中国计划生育学杂志》2021年第10期2162-2165,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨轻型地中海贫血孕妇血液特点及对妊娠结局的影响。方法:选择2013年1月—2020年7月本院收治的轻型地中海孕妇55例为地贫组,同期正常孕妇114例为对照组,检测孕晚期(孕28~41周)血液指标并分析妊娠结局。结果:地贫组与对照组比较红细胞平均体积(MCV)(70.67±1.10 fL、90.33±0.57fL)、红细胞平均血红蛋白量(MCH)(22.10±0.36 pg、29.81±0.24pg)及血红蛋白(Hb)值(94.33±1.95 g/L、118.33±1.18g/L)均低,血红细胞计数(RBC)高于对照组(4.31±0.10×10^(12)/L、3.95±0.04×10^(12)/L)(P<0.01);地贫组与对照组比较剖宫产率(27.3%、55.3%)、新生儿体重(3016.9±82.2g、3316.1±50.7g)、巨大儿比率(1.8%、10.5%)均低,低出生体重儿比率(12.7%、4.4%)、孕期输血率(12.7%、0.9%)均高(P<0.05);围产期并发症两组无差异(P>0.05);回归性分析并未发现地贫与妊娠期并发症间有显著关系。结论:轻型地中海贫血虽不会增加妊娠期并发症的发生率,但可增加低出生体重儿的风险。Objective:To investigate the blood characteristics of the pregnant women with mild thalassemia,and to study its influence on the pregnancy outcomes.Methods:55 pregnant women with mild thalassemia were selected in study group from January 2013 to July 2020,and 114 normal pregnant women were randomly selected in control group.The blood indexes during the third trimester of pregnancy(28 to 41 gestational weeks)of the women in the two groups were detected,and their pregnancy outcomes were analyzed.Results:The values of mean erythrocyte volume(MCV),mean erythrocyte hemoglobin volume(MCH),and hemoglobin(Hb)of the women in the study group were 70.67±1.10fl,22.10±0.36pg,and 94.33±1.95g/L,respectively,which were significant lower than those(90.33±0.57fL,29.81±0.24pg,and 118.33±1.18g/L,respectively)of the women in control group.The red blood cell count(RBC)of the women in the study group was 4.31±0.10×10^(12)/L,which was significant higher than that(3.95±0.04×10^(12)/L)of the women in the control group(P<0.01).The cesarean section rate(27.3%),neonatal weight(3016.9±82.2g),and macrosomia rate(1.8%)of the women in the study group were significant lower than those(55.3%,3316.1±50.7g,and 10.5%)of the women in the control group.The Low birth weight ratio(12.7%),and blood transfusion during pregnancy rate(12.7%)of the women in the study group were significant higher than those(4.4%and 0.9%)of the women in the control group(P<0.05).There was no significant difference in perinatal complications rate of the women between the two groups(P>0.05).Regression analysis found that thalassemia of the women had no significant relevant to their pregnancy complications.Conclusion:Mild thalassemia does not increase the incidence of pregnancy complications of women during pregnancy,but it does increase the risk of low birth weight.

关 键 词：孕晚期 轻型地中海贫血 血液特点 妊娠结局 

分 类 号：R714.254[医药卫生—妇产科学]